DEVELOPMENTAL EPIDEMIOLOGY OF ANXIETY IN PRESCHOOLERS

学龄前儿童焦虑的发展流行病学

• 批准号: 6684129
• 负责人: HELEN L. EGGER
• 金额: $ 16.52万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-16 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6684129
• 关键词: age difference; anxiety; anxiety disorders; behavioral /social science research tag; behavioral genetics; developmental psychology; diagnosis design /evaluation; disease /disorder etiology; disease /disorder proneness /risk; family structure /dynamics; gene environment interaction; human subject; interview; mental disorder diagnosis; mental health epidemiology; middle childhood (6-11); parent offspring interaction; patient oriented research; pediatrics; preschool child (1-5); psychological stressor; psychometrics; questionnaires; statistics /biometry; twin /multiplet

The purpose of this Mentored Patient-Oriented Research Career Development Award (K23) is to enable the candidate, a child psychiatrist, to became an independent research investigating the development pathways and causes of anxiety disorders in preschool children. The research goal is to place preschoolers' anxiety symptoms and disorders within the framework of developmental epidemiology by focusing on two questions: 1. What are the age-specific presentations of anxiety disorders in children ages 2 to 5 years old? (Nosology) 2. What are the relative contributions of genes and environment and their interaction in the early development of anxiety disorders? (etiology). This application details a program of training in infant/young child psychiatry, in behavioral and statistical genetics with an introduction to molecular genetics and genomics, and advanced training in pediatric anxiety disorders. The candidate is based in the Center for Developmental Epidemiology, Duke University Medical Center. Sponsors are child psychiatrists Adrian Angold MRCPsych (developmental psychopathology and measure development), Robert Emde MD, and Charles Zeanah MH (infant/young child psychiatry and assessment of young children), and John March MD (anxiety disorders). Lindon Eaves PhD, a leading behavioral geneticist, will provide mentoring in this area. The research plan includes: 1. A detailed review of current instrumentation for assessing preschool anxiety. 2. A pilot study of 60 children aged 36-72 months, using a multi-informant assessment protocol. DSM-IV and DC:0-3 diagnoses and symptoms will be assessed using the Preschool Age Psychiatric Assessment (PAPA), a structured parent interview developed by the candidate. 3. Analysis of data on 15,500 2-5 year-old twin pairs to examine the contributions of genes and shared and non-shared environmental factors to young children's anxiety symptoms. 4. Submission of an R01 application for a longitudinal, genetically-informed study of the development of anxiety disorders in preschool children. This work will make important contributions to the development of prevention and treatment interventions for young children and will contribute to our understanding of the etiology of childhood psychopathology.

这项以患者为导向的研究职业发展奖（K23）的目的是使儿童精神病学家候选人能够成为一名独立研究人员，调查学龄前儿童焦虑症的发展途径和原因。研究目标是将学龄前儿童的焦虑症状和障碍置于发展流行病学的框架内，重点关注两个问题： 1. 2 至 5 岁儿童焦虑障碍的年龄特异性表现是什么？ （疾病分类学） 2. 基因和环境及其相互作用在焦虑症早期发展中的相对贡献是什么？ （病因学）。该申请详细介绍了婴儿/幼儿精神病学、行为和统计遗传学方面的培训计划，并介绍了分子遗传学和基因组学，以及儿科焦虑症的高级培训。该候选人位于杜克大学医学中心发展流行病学中心。赞助者包括儿童精神病学家 Adrian Angold MRCPsych（发展精神病理学和衡量发展）、Robert Emde MD 和 Charles Zeanah MH（婴幼儿精神病学和幼儿评估）以及 John March MD（焦虑症）。领先的行为遗传学家 Lindon Eaves 博士将提供该领域的指导。研究计划包括： 1. 对当前评估学前焦虑的仪器进行详细审查。 2. 使用多信息评估方案对 60 名 36-72 个月的儿童进行了一项试点研究。 DSM-IV 和 DC:0-3 的诊断和症状将使用学龄前儿童精神评估 (PAPA) 进行评估，这是一种由候选人开发的结构化家长访谈。 3. 分析 15,500 对 2-5 岁双胞胎的数据，以检查基因以及共享和非共享环境因素对幼儿焦虑症状的影响。 4. 提交 R01 申请，对学龄前儿童焦虑症的发展进行纵向、遗传学研究。这项工作将为幼儿预防和治疗干预措施的发展做出重要贡献，并将有助于我们了解儿童精神病理学的病因学。