Longitudinal Functional Imaging of Early Childhood Anxiety Disorders

儿童早期焦虑症的纵向功能成像

基本信息

批准号：
7817109
负责人：
HELEN L. EGGER
金额：
$ 69.27万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-02 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7817109
关键词：
Adolescence Adolescent Adult Age Amygdaloid structure Anger Anterior Anxiety Anxiety Disorders Area Attention Behavioral Brain Caregivers Characteristics Child Childhood Cohort Studies Color Communities Corpus striatum structure Cross-Sectional Studies Cues Data Collection Development Diagnosis Disease Disease remission Emotions Evaluation Expectancy Eye Face Fright Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Funding Generalized Anxiety Disorder Hypersensitivity Image Lateral Lead Left Link Longitudinal Studies Magnetic Resonance Imaging Measures Mental Depression Mental disorders Modeling National Institute of Mental Health Nature Neurocognitive Neurosciences Nucleus Accumbens Nursery Schools Pattern Phenotype Prefrontal Cortex Preventive Intervention Primary Health Care Primates Process Recruitment Activity Rewards Risk Risk Factors Rodent Sampling Scanning Separation Anxiety Disorder Social Perception Social Phobia Stimulus Temperament Visual attention Work base brain behavior childhood anxiety cingulate cortex early childhood early onset emotion regulation meetings neural circuit neural patterning novel public health relevance relating to nervous system response social trait vigilance

项目摘要

DESCRIPTION (provided by applicant): Pediatric anxiety disorders, from preschool through adolescence, are prevalent, impairing, and associated with increased risk for depression and anxiety disorders in adulthood. We propose a longitudinal, cohort study of children diagnosed with three common anxiety disorders: social phobia (SoPh), separation anxiety disorder (SAD), and/or generalized anxiety disorder (GAD) as preschoolers (ages 2-5). We will employ functional magnetic resonance imaging (fMRI), and eye tracking to characterize the development and to identify the neural basis of deficits in emotion processing and social perception in young children diagnosed with these early onset anxiety disorders. We will recruit 180 subjects (120 with SAD, GAD and/or SoPh; 60 with no psychiatric disorder as preschoolers) one year after they participate in a current NIMH funded, cross-sectional study of preschool anxiety disorders in a representative sample of children recruited from pediatric primary care. The children will be followed annually across five years of data collection. Our aims are: (1) Identification of dysfunctions of the neural circuitry involved in emotion processing in children with preschool SAD, SoPh, and GAD (2) Examination of the mechanisms underlying the persistence and development of functional abnormalities in the neural circuitry involved in emotion processing in children with preschool SoPh, GAD, and SAD. PUBLIC HEALTH RELEVANCE: This proposed study has the potential to make substantial contributions to our understanding of the nature and development of the brain: behavior relationship in children with early onset anxiety disorders. It would also be the first longitudinal study of a representative sample of typically developing children using imaging and eye tracking approaches. This work will contribute to our understanding of early childhood mental health disorders and lead toward the development of reliable treatments and preventive interventions for young children with impairing anxiety.

描述（由申请人提供）：从学龄前到青春期的儿童焦虑症很普遍，会造成损害，并与成年后抑郁和焦虑症的风险增加相关。我们建议对学龄前儿童（2-5 岁）被诊断患有三种常见焦虑症的儿童进行纵向队列研究：社交恐惧症 (SoPh)、分离焦虑症 (SAD) 和/或广泛性焦虑症 (GAD)。我们将采用功能磁共振成像（fMRI）和眼动追踪来描述被诊断患有这些早发性焦虑症的幼儿的发展特征，并确定其情绪处理和社会感知缺陷的神经基础。我们将招募 180 名受试者（其中 120 名患有 SAD、GAD 和/或 SoPh；60 名学龄前儿童没有精神疾病），一年后他们将参加一项由 NIMH 资助的学前焦虑症横断面研究，研究对象是招募的儿童代表性样本来自儿科初级保健。在五年的数据收集过程中，每年都会对这些孩子进行跟踪调查。我们的目标是：(1) 识别学龄前 SAD、SoPh 和 GAD 儿童情绪处理相关神经回路的功能障碍 (2) 检查情绪相关神经回路功能异常持续和发展的潜在机制患有学龄前 SoPh、GAD 和 SAD 的儿童的处理。公共健康相关性：这项拟议的研究有可能为我们对大脑的本质和发育的理解做出重大贡献：早发性焦虑症儿童的行为关系。这也将是首次使用成像和眼动追踪方法对典型发育儿童的代表性样本进行纵向研究。这项工作将有助于我们对儿童早期心理健康障碍的理解，并为患有焦虑症的幼儿开发可靠的治疗方法和预防性干预措施。