Longitudinal Functional Imaging of Early Childhood Anxiety Disorders

儿童早期焦虑症的纵向功能成像

基本信息

批准号：
7817109
负责人：
HELEN L. EGGER
金额：
$ 69.27万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-02 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7817109
关键词：
Adolescence Adolescent Adult Age Amygdaloid structure Anger Anterior Anxiety Anxiety Disorders Area Attention Behavioral Brain Caregivers Characteristics Child Childhood Cohort Studies Color Communities Corpus striatum structure Cross-Sectional Studies Cues Data Collection Development Diagnosis Disease Disease remission Emotions Evaluation Expectancy Eye Face Fright Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Funding Generalized Anxiety Disorder Hypersensitivity Image Lateral Lead Left Link Longitudinal Studies Magnetic Resonance Imaging Measures Mental Depression Mental disorders Modeling National Institute of Mental Health Nature Neurocognitive Neurosciences Nucleus Accumbens Nursery Schools Pattern Phenotype Prefrontal Cortex Preventive Intervention Primary Health Care Primates Process Recruitment Activity Rewards Risk Risk Factors Rodent Sampling Scanning Separation Anxiety Disorder Social Perception Social Phobia Stimulus Temperament Visual attention Work base brain behavior childhood anxiety cingulate cortex early childhood early onset emotion regulation meetings neural circuit neural patterning novel public health relevance relating to nervous system response social trait vigilance

项目摘要

DESCRIPTION (provided by applicant): Pediatric anxiety disorders, from preschool through adolescence, are prevalent, impairing, and associated with increased risk for depression and anxiety disorders in adulthood. We propose a longitudinal, cohort study of children diagnosed with three common anxiety disorders: social phobia (SoPh), separation anxiety disorder (SAD), and/or generalized anxiety disorder (GAD) as preschoolers (ages 2-5). We will employ functional magnetic resonance imaging (fMRI), and eye tracking to characterize the development and to identify the neural basis of deficits in emotion processing and social perception in young children diagnosed with these early onset anxiety disorders. We will recruit 180 subjects (120 with SAD, GAD and/or SoPh; 60 with no psychiatric disorder as preschoolers) one year after they participate in a current NIMH funded, cross-sectional study of preschool anxiety disorders in a representative sample of children recruited from pediatric primary care. The children will be followed annually across five years of data collection. Our aims are: (1) Identification of dysfunctions of the neural circuitry involved in emotion processing in children with preschool SAD, SoPh, and GAD (2) Examination of the mechanisms underlying the persistence and development of functional abnormalities in the neural circuitry involved in emotion processing in children with preschool SoPh, GAD, and SAD. PUBLIC HEALTH RELEVANCE: This proposed study has the potential to make substantial contributions to our understanding of the nature and development of the brain: behavior relationship in children with early onset anxiety disorders. It would also be the first longitudinal study of a representative sample of typically developing children using imaging and eye tracking approaches. This work will contribute to our understanding of early childhood mental health disorders and lead toward the development of reliable treatments and preventive interventions for young children with impairing anxiety.

描述（由申请人提供）：从学龄前到青春期，小儿焦虑症普遍存在，损害，并且与成年后抑郁症和焦虑症的风险增加有关。我们提出了一项纵向，对诊断患有三种常见焦虑症的儿童的纵向研究：社交恐惧症（Soph），分离焦虑症（SAD）和/或普遍的焦虑症（GAD）为学龄前儿童（2-5岁）。我们将采用功能性磁共振成像（fMRI），并进行注视以表征发育，并确定情绪处理和社会知觉缺陷的神经基础，这些儿童被诊断出患有这些早期发作焦虑症的幼儿。在他们参加了一项现有的NIMH资助的NIMH资助的NIMH，对从儿科初级保健招募的儿童招募的儿童样本中，他们将招募180名受试者（120名患有SAD，GAD和/或Soph; 60没有精神病患者作为学龄前儿童）。在五年收集数据中，每年都会关注孩子们。我们的目的是：（1）鉴定患有学龄前儿童，Soph和Gad的儿童情绪处理的神经回路功能障碍（2）检查在患有学龄前儿童，GAD和GAD和SAD和SAD和SAD和SAD和SAD的儿童情绪处理中涉及的功能异常的持续性和功能异常的机制。公共卫生相关性：这项拟议的研究有可能为我们对大脑的性质和发展的理解做出重大贡献：早期发作焦虑症的儿童的行为关系。这也将是使用成像和眼动方法的典型发展儿童的代表性样本的纵向研究。这项工作将有助于我们对幼儿心理健康障碍的理解，并导致对焦虑症患者的可靠治疗和预防干预措施的发展。