The Social Context of HIV Post-Exposure Prophylaxis

HIV 暴露后预防的社会背景

• 批准号: 6799458
• 负责人: MICHELLE E ROLAND
• 金额: $ 16.67万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6799458
• 关键词: AIDS education /prevention; Africa; HIV infections; United States; adolescence (12-20); alcoholism /alcohol abuse; anxiety; behavioral /social science research tag; clinical research; coping; depression; disease /disorder proneness /risk; drug abuse; drug adverse effect; homosexuals; human subject; interview; mental health counseling; mental health epidemiology; psychological shock; psychological stressor; psychopharmacology; sex abuse; social psychology; stress; therapy compliance

DESCRIPTION (provided by applicant): My long-term career goal is to become a fully independent clinical investigator in the area of biomedical HIV prevention interventions that are integrated within a behavioral and mental health context. To accomplish this goal, I propose a career development plan that combines course work, seminars, workshops, and directed reading. I also propose two research projects that are designed to increase knowledge about the behavioral and psychosocial context in which HIV post-exposure prophylaxis (PEP) is currently used in high-risk populations, including men who have sex with men (MSM) in the United States (Study 1) and sexual assault survivors in South Africa (Study 2). I will obtain formal training in epidemiology, quantitative and qualitative research methods, and biostatistics through the 9-month Advanced Training in Clinical Research in the Department of Epidemiology, and a series of qualitative methods courses in the Department of Medical Anthropology, both at the University of California San Francisco (UCSF). In order to develop a more in-depth understanding of the social context in which HIV risk occurs, I have recruited nationally recognized experts in the areas of gender based violence (focusing on sexual violence and HIV transmission risk), mental health trauma (focusing on sexual assault), and international research ethics (focusing on the informed consent process), who will provide training through directed readings, seminars, workshops and regular supervisory meetings. I have assembled a distinguished group of mentors at UCSF and elsewhere, led by Thomas Coates, PhD, with whom I have a long-standing mentoring relationship. As my career development interests evolve, Dr. Coates' experience with international research and ethics, as well as behavioral and mental health approaches to HIV prevention, will be invaluable to my continued professional growth and independence. The research environment that I will be training in includes UCSF, San Francisco General Hospital and its largest division, the Positive Health Program (formerly called the AIDS Program). In addition, I will collaborate with investigators at the University of Cape Town, South Africa, where I will conduct research at several local hospitals (Groote Schuur and Jooste Hospitals in Cape Town and Eben Donges Hospital, a rural hospital in the Western Cape Province).

描述（由申请人提供）：我的长期职业目标是成为行为和心理健康背景下的生物医学艾滋病毒预防干预领域的完全独立的临床研究者。为了实现这一目标，我提出了一个结合了课程作业、研讨会、讲习班和定向阅读的职业发展计划。我还提出了两个研究项目，旨在增加对行为和心理社会背景的了解，其中艾滋病毒暴露后预防（PEP）目前在高危人群中使用，包括美国的男男性行为者（MSM）各州（研究 1）和南非的性侵犯幸存者（研究 2）。 我将通过流行病学系为期 9 个月的临床研究高级培训以及医学人类学系的一系列定性方法课程，获得流行病学、定量和定性研究方法以及生物统计学方面的正式培训加州大学旧金山分校 (UCSF)。为了更深入地了解艾滋病毒风险发生的社会背景，我招募了性别暴力（重点关注性暴力和艾滋病毒传播风险）、精神健康创伤（重点关注性侵犯）和国际研究伦理（重点关注知情同意过程），他们将通过定向阅读、研讨会、讲习班和定期监督会议提供培训。 我在加州大学旧金山分校和其他地方组建了一群杰出的导师，由托马斯·科茨博士领导，我与他有着长期的指导关系。随着我职业发展兴趣的发展，科茨博士在国际研究和伦理方面的经验，以及预防艾滋病毒的行为和心理健康方法，对于我持续的职业发展和独立性将是无价的。 我将接受培训的研究环境包括加州大学旧金山分校、旧金山总医院及其最大的部门积极健康计划（以前称为艾滋病计划）。此外，我将与南非开普敦大学的研究人员合作，在当地几家医院（开普敦的 Groote Schuur 和 Jooste 医院以及西开普省的一家乡村医院 Eben Donges 医院）进行研究。