Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) Clinical Research Center

使用证据对性和性别少数青少年进行弹性艾滋病毒实施科学 (RISE) 临床研究中心

• 批准号: 10749084
• 负责人: Sylvia Adebajo
• 金额: $ 125.29万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749084
• 关键词: AIDS prevention; Acceleration; Address; Affect; Africa; Africa South of the Sahara; African; Age; Baltimore; Behavioral; Case Management; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Centers for Population Health; Characteristics; Clinical Management; Clinical Research; Clinical effectiveness; Collaborations; Communities; Community Health; Consolidated Framework for Implementation Research; Continuity of Patient Care; Country; Cybersex; Data; Data Analyses; Development; Doctor of Medicine; Doctor of Philosophy; Epidemic; Equity; Goals; Guidelines; HIV; HIV Infections; HIV Seropositivity; Health; Health Services; Health education; Health system; High Prevalence; Human; Implementation readiness; Incidence; Interdisciplinary Study; International; Internet; Intervention; Kenya; Knowledge; Leadership; Malawi; Maryland; Morbidity - disease rate; Nigeria; Outcome; Penetration; Persons; Policies; Policy Making; Prevention; Prevention Research; Process; Randomized, Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Readiness; Recommendation; Research; Resources; Risk; Risk Reduction; Role; Scientist; Services; Sex Behavior; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Shapes; Site; Southern Africa; Strategic Planning; System; Testing; Translating; USAID; United States; Universities; Viral Load result; Vision; Work; Youth; Zambia; biosecurity; care systems; clinical implementation; community engagement; cost effectiveness; data management; data quality; design; digital health; effectiveness evaluation; effectiveness/implementation study; epidemic response; experience; follow-up; fortification; implementation science; implementation strategy; implementation/effectiveness; improved; international center; man; mortality; multidisciplinary; outreach; peer; pre-exposure prophylaxis; programs; provider adoption; resilience; seropositive; service delivery; service providers; sexual role; social; social stigma; transgender women; treatment as usual; trial design; uptake; virology; young men who have sex with men

PROJECT SUMMARY Sexual and gender minority (young men who have sex with men [YMSM] and young transgender women [YTW]) youths (ages 15-24 years) at risk of and living with HIV are poorly represented in international implementation science (IS) research. The overarching goal of Resilient HIV Implementation Science with SGM Youths using Evidence (RISE) Clinical Research Center is to make significant contributions to the development and conduct of IS studies to improve HIV prevention and care continuum (PHCC). A strategic planning process including a comprehensive review of our CRC's role in accelerating and maximizing the integration of digital health into practice, increasing the scientific capacity for IS research with SGM youths, translating findings to inform national and global guidelines on clinical management of SGM youths was conducted to inform this proposal. A vision statement encompassing four Themes – Equity in Partnerships for Access, Youth-tailored Intervention, Rigor IS Research, and Collaboration Capacity for Sustainability shapes our work. The RISE Clinical Research Center is a multidisciplinary research group composed of an administrative core at the University of Maryland Baltimore and five clinical research performing sites (CRPSs) that represent a network of implementing partners and community-based HIV service providers (CBSPs) in West, East, and Southern Africa: (1) Centre for Population Health Initiatives, Nigeria (CPHI); (2) Institute of Human Virology, Nigeria (IHVN); (3) Partners for Health & Development in Africa, Kenya (PHDA); (4) Centre for the Development of People (CEDEP); and (5) Center for International Health Education Biosecurity, Zambia (Ciheb Zambia). Together, we have over fifteen years of leadership experience in the design, implementation, and conduct of health service studies with SGM youths in SSA and the United States (US). Under the leadership of the multiple PIs, Man Charurat Ph.D, Lisa Hightow-Weidman M.D., Sylvia Adebajo, PhD, a youth and SGM service delivery and policy-making multidisciplinary investigative team together with representatives from AHISA in each country including Kate Muessig, Ph.D, – a behavioral scientist, Nadia Sam-Agudu M.D. – AHISA Nigeria, Kwango Agot Ph.D, M.P.H – AHISA Kenya, Nora Rosenberg, Ph.D. – AHISA Malawi, and Maurice Musheke, Ph.D. M.P.H – AHISA Zambia, we will participate in the adaptation and customization of a digital health platform and conduct its implementation to support PHCC among SGM youths. Centralized resources for regulatory compliance, data management, data quality, and data analysis across the CRPSs promote RISE CRC's efficiency and quality. Collaboration capacity with AHISA, health ministries, and youth advisory boards for community engagement, IS capacity development, and sustainability will promote RISE CRC's impact locally and globally.

项目摘要 性别和性别少数群体（与男人发生性关系的年轻男性和年轻的跨性别妇女 [YTW]）年轻人（15-24岁）处于艾滋病毒和艾滋病毒的风险和忍受 实施科学（IS）研究。具有韧性HIV实施科学的总体目标 使用证据（RISE）临床研究中心的SGM青年是为了为 IS的开发和行为以改善HIV预防和护理连续体（PHCC）。策略 计划过程，包括对我们CRC在加速和最大化CRC的作用的全面审查 将数字健康整合到实践中，提高SGM青年研究的科学能力， 将调查结果转化为有关SGM青年临床管理国家和全球全球指南的信息 进行该提议的通知。构成四个主题的愿景声明 - 合伙企业的股权 对于访问，青年审议的干预，严谨性是研究和协作能力 可持续性塑造了我们的工作。 Rise临床研究中心是一个多学科研究小组 由马里兰大学巴尔的摩大学和五项临床研究组成 表演网站（CRPS）代表实施合作伙伴和基于社区的艾滋病毒的网络 西部，东部和南部非洲的服务提供商（CBSP）：（1）人口健康计划中心， 尼日利亚（CPHI）； （2）尼日利亚人类病毒学研究所（IHVN）； （3）健康与发展合作伙伴 肯尼亚非洲（PHDA）； （4）人民发展中心（CEDEP）； （5）国际中心 卫生教育生物安全性，赞比亚（ciheb zambia）。在一起，我们有十五年的领导 在SSA和SSA的SGM年轻人和SSA和 美国（美国）。在多个PI的领导下，Man Charurat博士，Lisa Hightow-Weidman M.D.，Sylvia Adebajo博士，年轻人和SGM服务提供和政策制定多学科调查 团队以及来自每个国家 /地区的Ahisa代表，包括Kate Muessig，博士 - 行为 科学家，纳迪亚·萨姆·阿古杜（Nadia Sam-Agudu M.D.） - 尼日利亚阿希萨（Ahisa Nigeria） 罗森伯格博士 - Ahisa Malawi和Maurice Mushek博士M.P.H - Ahisa Zambia，我们将参加 在适应和定制数字健康平台并进行实施以支持 SGM青年中的PHCC。用于监管合规性，数据管理，数据质量的集中资源， CRPS的数据分析促进了CRC的效率和质量。协作能力 与AHISA，卫生部和社区参与的青年咨询委员会有关 发展和可持续性将促进CRC在本地和全球的影响。