Molecular analyses of vector/host-Leishmania Interaction

载体/宿主-利什曼原虫相互作用的分子分析

• 批准号: 6701742
• 负责人: Serap AKSOY
• 金额: $ 15万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6701742
• 关键词: Colombia; Leishmania; Psychodidae; South American; clinical research; communicable disease transmission; disease vectors; education evaluation /planning; epidemiology; health care personnel education; host organism interaction; human subject; international cooperation; leishmaniasis; molecular pathology; postgraduate education; training

DESCRIPTION (provided by applicant): The goal of the training grant is to build research capacity to identify strategies and devise means to interrupt the cycle of transmission and pathogenesis of leishmaniasis through intervention of the invertebrate and vertebrate host pathogen interactions. To achieve this goal, the training program will implement research capacity in the molecular analysis of the interaction between Leishmania and both the sandfly vector and the mammalian host. The proposed program builds upon the existing research capacity and ongoing projects of the developing country institution in clinical, epidemiological and biological aspects of cutaneous and visceral leishmaniasis and other transmissible diseases, prior collaboration with Yale faculty, and the critical mass of faculty and infrastructure for the conduct of molecular analyses of kinetoplastid parasites and host responses available at Yale University. Colombian scientists will receive training at Yale through the conduct of mentored research, auditing of postgraduate courses and short courses on research skills, such as biosafety, responsible conduct of research, and scientific writing. Workshops will be offered each year at CIDEIM with the participation of Yale Faculty (on site and teleconferencing) to build and multiply research skills and introduce national investigators to concepts and principles of molecular analysis (bioinformatics and data mining, functional genomics, expression analysis). Predoctoral trainees will be selected among postgraduate students from Colombian universities who conduct thesis research in CIDEIM. Students will be recent graduates of human or veterinary medicine and basic science who have qualified for scholarship support within the framework of COLCIENCIAS' Young Investigator program. Post-doctoral training and scientific exchange for periods of up to 4 months will be available to research staff of CIDEIM whose research is relevant to the vector or host- Leishmania interaction. During year 5 of the program, formal postgraduate courses on the molecular genetic analyses of host (mammalian/vector)-pamsite interactions will be offered to national and regional students by CIDEIM. Overall, the training conducted will prepare investigators in new areas of research, implement training by teleconferencing, and assure the capacity to offer formal courses for Colombian and regional post-graduate students. All of these will contribute to the sustainability of research capacity.

描述（由申请人提供）：培训赠款的目的是建立研究能力，以确定策略和设计方法，通过干预无脊椎动物和脊椎动物宿主的病原体相互作用来中断利什曼病的传播和发病机理。为了实现这一目标，培训计划将在利什曼尼亚与桑德弗载体和哺乳动物宿主之间相互作用的分子分析中实施研究能力。 The proposed program builds upon the existing research capacity and ongoing projects of the developing country institution in clinical, epidemiological and biological aspects of cutaneous and visceral leishmaniasis and other transmissible diseases, prior collaboration with Yale faculty, and the critical mass of faculty and infrastructure for the conduct of molecular analyses of kinetoplastid parasites and host responses available at Yale University.哥伦比亚科学家将通过进行指导研究，研究生课程的审核以及研究技能的简短课程，例如生物安全，负责任的研究和科学写作等简短课程，在耶鲁大学接受培训。耶鲁大学教职员工（在现场和远程会议上）的参与，每年将在Cideim举办研讨会，以建立和繁殖研究技能，并将国家研究人员介绍到分子分析的概念和原理（生物信息学和数据挖掘，功能性基因组学，表达分析）。将在哥伦比亚大学的研究生中选拔托尔德学员。学生将成为最近在Colciencias的年轻研究者计划框架内获得奖学金支持的人类或兽医医学和基础科学的毕业生。博士的研究人员将获得最多4个月期间的博士后培训和科学交流，他们的研究人员的研究与矢量或寄主利什曼尼亚相互作用有关。在该计划的第5年中，凯迪姆将向国家和地区学生提供有关宿主分子遗传分析（哺乳动物/矢量） - pamsite相互作用的正式研究生课程。总体而言，进行的培训将使研究人员在新的研究领域，通过电信实施培训，并确保为哥伦比亚和地区研究生提供正式课程的能力。所有这些都将有助于研究能力的可持续性。