The Effects of Alcohol on Fetal Cerebral Blood Flow

酒精对胎儿脑血流量的影响

• 批准号: 6691456
• 负责人: Scott Parnell
• 金额: $ 2.77万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6691456
• 关键词: alcoholism /alcohol abuse; alcohols; blood toxicology; brain circulation; brain injury; developmental neurobiology; drug habituation; embryo /fetus toxicology; microcapsule; neurogenesis; neuropharmacology; neurotoxicology; predoctoral investigator; radiotracer; sheep

DESCRIPTION (provided by applicant): The purpose of this proposal is to investigate the effects of alcohol exposure on cerebral blood flow during the third trimester in sheep. Neurological deficits are the most devastating consequences of maternal alcohol abuse. In spite of the huge research literature on this subject, surprisingly little is known about the mechanisms underlying alcohol's effects. One possible mechanism may be associated with fetal cerebral blood flow, since the neurovasculature is so important for proper neurodevelopment. The data generated from this proposal will help to further our understanding of the mechanisms of fetal alcohol-induced brain damage. The goals will be addressed in two specific aims using a sheep model system. SPECIFIC AIM #1 will test the hypothesis that repeated alcohol exposure will adversely affect fetal cerebral blood flow. SPECIFIC AIM #2 will test the hypothesis that repeated alcohol exposure will affect the neurovascular responsiveness to acute alcohol exposure. These experiments will be performed using the sheep model system in order to maintain an intact maternal/fetal unit. Regional blood flow will be measured in fetal sheep in utero using radiotabelled microspheres. Understanding alcohol's effects during development will be helpful in the future for guiding prevention and therapy strategies.

描述（由申请人提供）：本提案的目的是研究酒精暴露对绵羊妊娠晚期脑血流的影响。神经系统缺陷是母亲酗酒最具破坏性的后果。尽管关于这个主题的研究文献很多，但令人惊讶的是，人们对酒精影响的机制知之甚少。一种可能的机制可能与胎儿脑血流量有关，因为神经血管系统对于正常的神经发育非常重要。该提案产生的数据将有助于进一步了解胎儿酒精引起的脑损伤的机制。这些目标将通过使用绵羊模型系统来实现两个具体目标。具体目标#1 将检验反复接触酒精会对胎儿脑血流量产生不利影响的假设。具体目标#2 将检验以下假设：反复接触酒精会影响神经血管对急性酒精接触的反应。这些实验将使用绵羊模型系统进行，以保持完整的母体/胎儿单位。将使用放射性标记的微球测量子宫内胎羊的局部血流量。了解酒精在发育过程中的影响将有助于将来指导预防和治疗策略。