Delineating the Externalizing Construct & Its Facets

描述外化结构

• 批准号: 6794725
• 负责人: CHRISTOPHER JOHN PATRICK
• 金额: $ 47.3万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794725
• 关键词: abnormal psychology; alcoholism /alcohol abuse; antisocial personality; behavioral /social science research tag; behavioral genetics; clinical research; correctional institutions; criminal behavior; drug addiction; evoked potentials; human subject; impulsive behavior; interview; locus of control; model design /development; personality; psychological models; psychological tests; psychometrics; questionnaires; social behavior disorders; suicide; twin /multiplet; violence

DESCRIPTION (provided by applicant): Five years of funding are sought to pursue translational research on the externalizing spectrum of personality and psychopathology. The externalizing spectrum is conceived of as a coherent set of personality traits and psychopathological syndromes characterized by a lack of impulse control. At the highest level within this spectrum stands a variable that links specific externalizing disorders and traits, the externalizing dimension. Recent research demonstrates both the existence and high heritability of this dimension via significant observed (phenotypic) and etiological (genetic) connections between an unconstrained, impulse-driven personality style and psychopathological syndromes involving antisocial behavior and substance dependence. This application seeks to build on these preliminary data by pursuing three specific aims. First, quantitative models of behaviors in the externalizing spectrum will be built by developing a hierarchical model of the externalizing spectrum that links the broad externalizing dimension to its manifestations as specific traits and syndromes. Second, models of externalizing behavior will be linked to models of neurocognitive processing, with a particular focus on event related potentials, to characterize the biobehavioral bases of externalizing behavior. Third, high levels of externalizing will be studied in criminal offender samples to characterize the implications of the externalizing spectrum model for understanding behaviors with high social costs, such as reactive violence and impulsive suicide attempts. This research is designed to realize the aims of the RFA to which it is a response by integrating ideas from diverse scientific areas (ranging from statistical modeling to cognitive neuroscience), in linking basic methodological advances in these areas to a broad range of costly, impulsive behaviors in both clinical and non-clinical samples.

描述（由申请人提供）：寻求五年的资金来追求 关于人格外在化范围和的转化研究 心理病理学。外部化频谱被认为是连贯的集合 人格特征和精神病理学综合症的特征是缺乏 冲动控制。在该频谱中的最高级别是一个变量 链接特定的外在疾病和特征，外部化 方面。最近的研究表明了存在和高 通过大量观察（表型）和 病因（遗传）连接，不受约束，冲动驱动 涉及反社会的人格风格和精神病理综合症 行为和物质依赖性。该应用程序旨在以这些为基础 通过追求三个特定目标来初步数据。首先，定量模型 外部化频谱中的行为将通过开发一个 外部化频谱的分层模型，该模型连接了广泛 将其表现为特定特征和综合征的表现。 其次，外部化行为的模型将链接到 神经认知处理，特别关注与事件相关的潜力， 表征外在行为的生物行为基础。第三，高 将在刑事罪犯样本中研究外部化水平 表征外在频谱模型对 了解具有高昂社会成本的行为，例如反应性暴力和 冲动自杀的尝试。这项研究旨在实现 通过整合来自各种科学的思想的RFA，它是一种回应 区域（从统计建模到认知神经科学） 这些领域的基本方法论进步至广泛的昂贵， 临床和非临床样本中的冲动行为。