CORE--RESEARCH ANIMAL FACILITY

核心——研究动物设施

• 批准号: 6413594
• 负责人: GORDON C HARD
• 金额: $ 24.29万
• 依托单位: INSTITUTE FOR CANCER PREVENTION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-26 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6413594
• 关键词: animal breeding; animal care; animal colony; biomedical facility; laboratory mouse; laboratory rabbit; laboratory rat

The Research Animal Facility (RAF) of the AHFCC is a centralized unit located in the Naylor Dana Institute for Disease Prevention (NDI), representing the only resource for housing laboratory animals within the AHF. The objectives of the facility are to maintain research animals according to the principles of proper animal care and use, and to generate quality research data from the conduct of animal experiments. The facility not only provides routine animal care and maintenance through a team of trained animal care technicians, but also provides a specialized service for conducting the procedures involved in animal experimentation carried out by a team of skilled, qualified research biologists. The RAF occupies a net of 10,030 square feet (14,200 gross square feet) designed around a conventional clean, dirty corridor system supporting a cage-wash area and a central bank of 14 animal holding rooms for rodents and rabbits only. Special purpose areas include two quarantine rooms; a semi-barrier room for immunodeficient mice; three treatment rooms when biocontainment or canopy hoods; metabolism, necropsy and clinical laboratories, food and bedding storage rooms; and diet mixing kitchen. The facility has its own air-handling system which maintains on average a temperature of 72 +/-8 degrees Fahrenheit and relative humidity of 50 +/-10% providing 15-20 changes of fresh air per hour to the animal rooms. The facility is also fitted with an automated watering system. The RAF operatives strictly according to regulatory guidelines. The animal care and use program is monitored by a 9-member Institutional Animal Care and Use Committee(IACUC) which ensures compliance with Public Health Service policy regarding welfare and humane treatment of laboratory animals. The Committee includes the Attending Veterinarian, an external non-affiliated lay-person, and scientific and non-scientific AHF staff. The facility has received full accreditation by the American Association for Accreditation of Laboratory Animal Care (AAALAC) since being established in 1976, and come under triennial site-review to maintain this status. The facility is also inspected on a regular basis each year by both Federal and State governments and periodically by officers of the Food and Drug Administration. The AHF Biosafety and Biohazard Facility monitors the use of hazardous chemicals and other agents within the facility.

AHFCC 的研究动物设施 (RAF) 是一个集中单位 位于内勒达纳疾病预防研究所 (NDI)， 代表了该地区内饲养实验动物的唯一资源 急性心力衰竭。该设施的目标是维持研究动物 根据适当的动物护理和使用原则，并产生 来自动物实验的高质量研究数据。设施 不仅通过团队提供日常动物护理和维护 训练有素的动物护理技术人员，还提供专门的服务 用于进行动物实验所涉及的程序 由技术精湛、合格的研究生物学家团队开发。英国皇家空军占领 净面积 10,030 平方英尺（总面积 14,200 平方英尺），围绕 传统的清洁、肮脏走廊系统，支持笼子清洗区域和 中央银行有 14 个动物收容室，仅供啮齿类动物和兔子使用。 特殊用途区域包括两个隔离室；半屏障房间 对于免疫缺陷小鼠；三个治疗室，当生物防护或 天篷罩；新陈代谢、尸检和临床实验室、食品和 床上用品储藏室；和饮食混合厨房。该设施拥有自己的 空气处理系统平均温度保持在 72 +/-8 华氏度和相对湿度 50 +/-10%，提供 15-20 动物房每小时更换一次新鲜空气。该设施还 配备自动浇水系统。英国皇家空军特工严格 根据监管指南。动物护理和使用计划是 由 9 名成员组成的机构动物护理和使用委员会 (IACUC) 监督 确保遵守公共卫生服务政策 实验动物的福利和人道待遇。该委员会包括 主治兽医、外部非附属非专业人士，以及 科学和非科学的 AHF 工作人员。该设施已全部接收 美国实验室认可协会认可 动物护理协会 (AAALAC) 自 1976 年成立以来，隶属于 每三年进行一次现场审查以维持这一状态。该设施还 每年由联邦和州定期检查 政府并定期由食品和药品管理局官员 行政。 AHF 生物安全和生物危害设施监控使用情况 设施内的危险化学品和其他制剂。