CORE--RESEARCH ANIMAL FACILITY

核心——研究动物设施

• 批准号: 6605464
• 负责人: GORDON C HARD
• 金额: $ 24.29万
• 依托单位: INSTITUTE FOR CANCER PREVENTION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605464
• 关键词: Rodentias; animal breeding; animal care; animal colony; biomedical facility; laboratory rabbit

The Research Facility (RAF) of the AHFCC is a centralized unit located in the Naylor Dana Institute for Disease Prevention (NDI), representing the only resource for housing laboratory animals within the AHF. The objectives of the facility are to maintain research animals according to the principals of proper animal care and use, and to generate quality research data from the conduct of animal experiments. The RAF is considered a specialized facility because it not only provides routine animal care and maintenance through a team of trained animal care technicians, but also provides a special service for conducting the procedures involved in animal experimentation of behalf of investigators, carried out a team of skilled and qualified research biologists. The Chief of the Facility is Dr. Gordon C. Hard, who has a veterinary degree and certifications in laboratory animal science, toxicologic pathology, and general toxicology. The Attending Veterinarian is a consultant, Elihu Bond, D.V.M., who inspects the facility on a once-per-month basis, but is available for consultation at any time. The RAF occupies a net area of 12,310 square feet (14,200 gross square feet) designed around a conventional clean/dirty corridor system supporting a cage-wash area and a central bank of 14 animal holding rooms for rodents and rabbits only. Special purpose areas include two quarantine rooms: a semi-barrier room for immunodeficient mice, three treatment rooms with biocontainment or canopy hoods; metabolism, necropsy and clinical laboratories; food and bedding storage rooms, an diet-mixing kitchen. The facility has its own air-handling system which maintains on average a temperature of 72+/-8 degrees Fahrenheit and relative humidity of 50+/-10% providing 15-20 changes of fresh air per hour to the animal rooms. The facility is also fitted with an automated watering system. The RAF operates strictly according to regulatory guidelines. The animal care and use program is monitored by a 9-member Institutional Animal Care and Use Committee (IACUC) which ensures compliance with Public Health Service policy regarding welfare and human treatment of laboratory animals (Assurance no. A3293-01). The Committee includes the Attending Veterinarian, an external non-affiliated layperson, and scientific and non-scientific AHF staff. The facility has received full accreditation by the American Association for Accreditation of Laboratory Animal Care (AAALAC) since being established in 1976, and comes under triennial site-review to maintain this status. The facility is also inspected on a regular basis each year by both Federal and State governments. The AHF Biosafety and Biohazard Facility monitors the use of hazardous chemicals and other agents within the facility. NCI-funded new construction currently underway will provide office space for the RAF staff, as well as for relocation of a refurbished necropsy room.

AHFCC 的研究设施 (RAF) 是位于内勒达纳疾病预防研究所 (NDI) 的一个集中单位，是 AHF 内饲养实验动物的唯一资源。该设施的目标是根据适当的动物护理和使用原则来维持研究动物，并通过动物实验产生高质量的研究数据。英国皇家空军被认为是一个专门机构，因为它不仅通过训练有素的动物护理技术人员团队提供日常动物护理和维护，而且还为代表研究人员进行动物实验所涉及的程序提供特殊服务，由一组熟练且合格的研究生物学家。该机构的负责人是 Gordon C. Hard 博士，他拥有兽医学位以及实验动物科学、毒理学病理学和普通毒理学方面的认证。主治兽医是一名顾问，Elihu Bond，D.V.M.，他每月检查一次设施，但可以随时接受咨询。英国皇家空军占地 12,310 平方英尺（总面积 14,200 平方英尺），围绕传统的清洁/肮脏走廊系统设计，支持笼子清洗区和中央银行，该系统由 14 个仅用于啮齿动物和兔子的动物饲养室组成。特殊用途区域包括两个检疫室：一个用于免疫缺陷小鼠的半屏障室，三个带有生物防护或天篷罩的治疗室；代谢、尸检和临床实验室；食物和床上用品储藏室、饮食混合厨房。该设施拥有自己的空气处理系统，平均温度保持在 72+/-8 华氏度，相对湿度为 50+/-10%，每小时为动物房提供 15-20 次新鲜空气。该设施还配备了自动浇水系统。英国皇家空军严格按照监管指南运作。动物护理和使用计划由 9 名成员组成的机构动物护理和使用委员会 (IACUC) 监督，确保遵守有关实验动物福利和人类待遇的公共卫生服务政策（保证编号 A3293-01）。该委员会包括主治兽医、外部非附属外行人员以及 AHF 科学和非科学工作人员。该设施自 1976 年成立以来已获得美国实验动物护理认证协会 (AAALAC) 的全面认证，并每三年进行一次现场审查以维持这一地位。该设施每年还接受联邦和州政府的定期检查。 AHF 生物安全和生物危害设施监控设施内危险化学品和其他制剂的使用情况。目前正在进行的由 NCI 资助的新建筑将为英国皇家空军工作人员提供办公空间，并用于搬迁翻新后的尸检室。