Ethanol and Social Interactions in Adolescent Rats

乙醇与青春期大鼠的社会互动

• 批准号: 6699691
• 负责人: ELENA I VARLINSKAYA
• 金额: $ 22.58万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6699691
• 关键词: adrenocorticotropic hormone; age difference; alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; corticosterone; drug tolerance; ethanol; juvenile animal; laboratory rat; motivation; neuropsychology; social behavior; socioenvironment; substance abuse related behavior

DESCRIPTION (provided by applicant): First experiences with alcohol in humans occur predominantly in adolescence, and drinking in a context of social interactions appears to be a virtually universal situation. Attractiveness of ethanol at this age is predominantly based on its properties to produce social facilitation and alleviate anxiety, since a high significance of social interactions, high social motivation and high frequency of anxiogenic situations characterize adolescence as a developmental period. Age-specific neural alterations also make adolescents notably hyposensitive to a number of the effects of ethanol. Therefore, the high risk of extensive alcohol use in adolescence is determined by a unique combination of social, motivational, environmental and neurobehavioral factors. Given that certain behavioral features, including age-related increase in social behavior, are common among adolescents of different mammalian species, peer-directed social activity of adolescent rats appears to have promise as an experimental model for the study of adolescent responsiveness to ethanol. The present proposal is to investigate how social and environmental factors contribute to responsiveness to ethanol in adolescence. Specifically, the proposed experiments will explore acute effects of ethanol on different forms of social behavior and social motivation in familiar and unfamiliar (anxiogenic) environments. Testing in a familiar environment will assess age-related differences in sensitivity of social behavior to activating and suppressing effects of ethanol, whereas testing in an unfamiliar environment will provide information about age-related differences in sensitivity to the anxiolytic effects of ethanol. Given that responsiveness to ethanol can be modified dramatically by repeated administrations, and that the emergence of these adaptations may also vary with age, the proposed experiments will investigate age-related peculiarities in the development of chronic tolerance to inhibitory effects of ethanol on social behavior as well as to its anxiolytic effects. Comparison of ethanol effects in weanling, adolescent and adult rats will allow us to outline peculiarities of adolescent responding to ethanol that may be unique to adolescence as a developmental period.

描述（申请人提供）：人类酒精的首次体验 主要发生在青春期，并在社会背景下喝酒 互动似乎实际上是普遍的情况。吸引力 乙醇在这个时代主要取决于其产生社会的特性 促进和减轻焦虑，因为社会具有很高的意义 互动，高度社交动机和高频的焦虑症 情况将青春期描述为发展时期。特定年龄 神经改变也使青少年特别对许多人不敏感 乙醇的作用。因此，大量饮酒的高风险 青春期是由社会，动机， 环境和神经行为因素。考虑到某些行为 特征，包括与年龄相关的社会行为增加，很常见 不同哺乳动物物种的青少年，以同行指导的社会活动 青少年大鼠似乎有希望作为研究的实验模型 青少年对乙醇的反应能力。目前的建议是调查 社会和环境因素如何有助于对乙醇的反应 青春期。具体而言，提出的实验将探索急性效应 在不同形式的社会行为和社会动机上的乙醇 熟悉和陌生的（焦虑）环境。在一个熟悉的 环境将评估与年龄有关的社会敏感性差异 激活和抑制乙醇作用的行为，而测试 一个陌生的环境将提供有关年龄有关的信息 对乙醇抗焦虑作用的敏感性差异。鉴于 对乙醇的反应可以通过重复进行大力修饰 行政部门，这些改编的出现也可能因 年龄，提出的实验将研究与年龄相关的特点 发展对乙醇对社会抑制作用的慢性耐受性 行为及其抗焦虑作用。比较乙醇作用 断奶，青少年和成年大鼠将允许我们概述 青春期对乙醇的反应可能是青春期独有的 发展时期。