Genomic and Proteomic Study of Cancer Disparities in Et*

Et* 癌症差异的基因组和蛋白质组研究

• 批准号: 6604693
• 负责人: LISA C. FLOWERS
• 金额: $ 17.42万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6604693
• 关键词: clinical research; cooperative study; functional /structural genomics; genetic polymorphism; health science research potential; neoplasm /cancer epidemiology; proteomics; racial /ethnic difference

DESCRIPTION: (Applicant's Description) This proposal seeks to devise a working plan for establishing a long-term collaboration between Clark Atlanta University and Emory School of Medicine, Winship Cancer Institute. Clark Atlanta University, a historically comprehensive Blaek University and Winship Cancer Institute are only a few miles apart but have not had extensive collaborations in the past. The objectives of this proposal are to plan, and establish new collaborations and research efforts, and to expand existing collaborations between Clark Atlanta University and the Winship Cancer Institute. The emphasis of this collaboration is the study of cancer disparities between ethnic populations using genomic and proteomic approaches. The honest evaluation and mutual respect of each institutions' strengths and weaknesses are recognized, allowing for organized development of collaborative arrangements that make best use of each institutions resources. This proposal intends to further develop pilot research projects, to conduct at each institution regular seminars, and quarterly advisory meetings over the term of the grant. Using microarray technology, phage display and mutational analysis collaborators at Clark Atlanta University and Emory School of Medicine, Winship Cancer Institute will directly address in differences between the gene and antigen expression profiles and mutational events that could illuminate the differences in cancer occurrence between the two populations. The final goal of this project is to generate more funding opportunities (i.e. R-series grants) for Clark Atlanta University and to provide an increasing involvement of Winship Cancer Institute in the study of cancer disparities between ethnic populations.

描述：（申请人的描述）该提案旨在设计一个 建立克拉克亚特兰大之间长期合作的工作计划 Winship癌症研究所大学和埃默里医学院。克拉克 亚特兰大大学，历史悠久的Blaek大学和胜利 癌症研究所相隔几英里，但没有广泛 过去的合作。该提议的目标是计划，并且 建立新的合作和研究工作，并扩展现有 克拉克亚特兰大大学与胜利癌的合作 研究所。这种合作的重点是癌症的研究 使用基因组和蛋白质组学方法之间的种族人群之间的差异。 每个机构优势的诚实评估和相互尊重， 认识到弱点，可以进行协作的组织发展 充分利用每个机构资源的安排。这个建议 打算进一步开发试点研究项目，以在每个项目上进行 机构定期研讨会和季度咨询会议 赠款。使用微阵列技术，噬菌体显示和突变分析 克拉克亚特兰大大学的合作者和埃默里医学院 Winship Cancer Institute将直接解决基因之间的差异 以及可以照亮的抗原表达曲线和突变事件 两个人群之间的癌症发生差异。决赛 该项目的目标是产生更多的资金机会（即R系列 赠款）为克拉克·亚特兰大大学（Clark Atlanta University）提供越来越多的参与 Winship Cancer Institute在研究种族差异的研究中 人群。