Network for Premature Birth Research Analytical Core

早产研究分析核心网络

• 批准号: 6943666
• 负责人: SAMUEL I. PARRY
• 金额: $ 84.07万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943666
• 关键词: bioinformatics; biomarker; biomedical resource; biotechnology; cervical /vaginal smear; clinical research; cooperative study; functional /structural genomics; genetic markers; high throughput technology; human genetic material tag; human subject; linkage mapping; microarray technology; nucleic acid amplification techniques; oxidative stress; premature infant human; premature labor; proteomics; statistics /biometry; women' s health

DESCRIPTION (provided by applicant): This proposal is submitted to create an Analytical Core, which will serve the Genomic and Proteomics Network for Premature Birth Research. The Analytical Core will have five components that will meet the needs for 1) sample processing, storage and distribution/retrieval; 2) high-throughput genotyping and interpretation of genetic studies; 3) microarray analysis and data mining; 4) proteomics, lipidomics and assessment of oxidative stress; and 5) Bioinformatics and statistics. Each component of this Core will be supervised by an established investigator with expertise in the specific methodology and data interpretation. The overall coordination of Analytical Core 1 functions will be the responsibility of the Principal Investigator who will also serve as the Director of the sample processing, storage, distribution/retrieval component and administrative unit (Jerome F. Strauss, III, M.D., Ph.D.), working in concert with the component facility directors (Genotyping and genetic analysis: Richard S. Spielman, Ph.D.; Microarray: Don Baldwin Ph.D.; Proteomics/lipidomics and oxidative stress: Ian Blair, Ph.D.: Bioinformatics and statistics: David Fenstermacher, Ph.D.) who will serve as the Analytical Core Steering Committee. The Principal Investigator will serve as the Steering Committee Chair and the interface with the other investigators and N.I.C.H.D. staff participating in this program. The proposed Core builds on established strengths of the University of Pennsylvania in the study of the genetics of preterm birth, the genetics of complex traits, proteomics, the study of oxidative stress biomarkers, and microarray analysis. The existing facilities are prepared to accommodate high-throughput assays. In addition, the Core key personnel can provide expert advice in study design and data analysis. A Concept Protocol built around the use of admixture mapping and the transmission disequilibrium test to identify the impact of ancestry on preterm birth and neonatal outcomes after preterm delivery as well as association and linkage studies to identify specific risk promoting and protective genes, and parent of origin effects.

描述（由申请人提供）：提交本提案是为了创建一个分析核心，该核心将为早产研究的基因组和蛋白质组学网络服务。分析核心将具有五个组件，可满足 1) 样品处理、存储和分发/检索的需求； 2）高通量基因分型和遗传研究的解释； 3）微阵列分析和数据挖掘； 4）蛋白质组学、脂质组学和氧化应激评估； 5) 生物信息学和统计学。 该核心的每个组成部分将由在特定方法和数据解释方面具有专业知识的资深调查员监督。 分析核心 1 职能的整体协调将由首席研究员负责，他还将担任样本处理、储存、分发/检索部分和行政部门的主管（Jerome F. Strauss, III, M.D., Ph.D） .)，与组成设施主管合作（基因分型和遗传分析：Richard S. Spielman 博士；微阵列：Don Baldwin 博士；蛋白质组学/脂质组学和氧化应激：Ian Blair 博士：生物信息学和统计学：David Fenstermacher 博士），他将担任分析核心指导委员会。首席研究员将担任指导委员会主席，并与其他研究人员和 N.I.C.H.D 进行沟通。参与该计划的工作人员。拟议的核心建立在宾夕法尼亚大学在早产遗传学、复杂性状遗传学、蛋白质组学、氧化应激生物标志物研究和微阵列分析研究方面的既定优势的基础上。现有设施已准备好适应高通量测定。此外，核心关键人员可以在研究设计和数据分析方面提供专家建议。围绕使用混合图谱和传递不平衡测试确定血统对早产和早产后新生儿结局的影响以及关联和连锁研究以确定特定风险促进和保护基因以及起源父母的概念方案影响。