CHROMOSOME 3P RECESSIVE ONCOGENES IN CERVICAL CANCER

宫颈癌中的染色体 3P 隐性癌基因

• 批准号: 2545448
• 负责人: LISA C. FLOWERS
• 金额: $ 6.3万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2545448
• 关键词: cervix neoplasms; clinical research; female; genetic mapping; genetic markers; human genetic material tag; human subject; molecular oncology; neoplasm /cancer diagnosis; neoplasm /cancer genetics; oncogenes; polymerase chain reaction; tumor suppressor genes; uterus preneoplastic state

DESCRIPTION (Applicant's Description): The candidate, Lisa Cecile Flowers, M.D., is an obstetrician gynecologist of Cuban and African-American descent. She seeks a career in academic gynecologic oncology. She intends to pursue that career in institutions that will allow her to positively impact the care of Hispanic and African-American women with cancer. Accordingly, she will begin a four-year fellowship in gynecologic oncology on July 1, 1996 that is sponsored by the Division of Gynecologic Oncology of the Department of Obstetrics and Gynecology and Harold C. Simmons Cancer Center at the University of Texas Southwestern Medical Center at Dallas. The first two years of the fellowship will be devoted to acquiring basic research skills in the gynecologic oncology molecular biology laboratories in the Hamon Center for Therapeutic Oncology Research. During this time she will address genetic alterations in the progression of dysplasia to cervical carcinoma, a disease more prevalent in disadvantaged and minority women. The final two years of the fellowship involve the clinical training required by the American Board of Obstetrics and Gynecology for a Certificate of Special Competence in Gynecologic Oncology. That will be carried out in the affiliate institutions of the U.T. Southwestern Medical Center: Parkland Memorial Hospital, Zale Lipshy University Hospital, St. Paul Medical Center, and Presbyterian Hospital where she will receive training in chemotherapy, radial pelvic and reconstructive surgery, radiation therapy, critical care, clinical trials and investigational agents. Most of her clinical training will be obtained at the Parkland Memorial Hospital where the preponderance of patients are disadvantaged and/or Hispanic or African-American. The receipt of the minorities in medical oncology grant will greatly facilitate Dr. Flowers' ability to accomplish her career goals and serve minority women with cancer.

描述（申请人的描述）： 候选人丽莎·塞西尔·弗洛斯（Lisa Cecile Flowers）医学博士是 古巴和非裔美国人血统。 她寻求学术职业 妇科肿瘤学。 她打算在机构中从事这一职业 这将使她能够积极影响西班牙裔和 非裔美国妇女患有癌症。 因此，她将开始四年 1996年7月1日，妇科肿瘤学奖学金由 妇产科肿瘤学系 德克萨斯大学的妇科和哈罗德·C·西蒙斯癌症中心 达拉斯的西南医疗中心。 前两年 奖学金将致力于获得基础研究技能 哈蒙中心的妇科肿瘤学分子生物学实验室 治疗性肿瘤学研究。 在此期间，她将解决遗传 发育不良向宫颈癌的进展改变，一种疾病 在不利的和少数族裔妇女中更普遍。 最后两年 奖学金涉及美国董事会要求的临床培训 具有特殊能力证书的产科和妇科 妇科肿瘤学。 这将在会员中进行 联合国机构西南医学中心：帕克兰纪念馆 医院，Zale Lipshy大学医院，圣保罗医疗中心， 长老会医院将接受化学疗法培训， 径向骨盆和重建手术，放射治疗，重症监护， 临床试验和研究代理。 她的大部分临床培训 将在帕克兰纪念医院获得优势 患者处于不利地位和/或西班牙裔或非裔美国人。 这 收到医学肿瘤学少数群体的赠款将极大地促进 Flowers博士实现自己的职业目标并为少数族裔女性服务的能力 癌症。