ANTI-HIV-1 EFFECTS OF IL-13 ON MACROPHAGES AND T CELLS

IL-13 对巨噬细胞和 T 细胞的抗 HIV-1 作用

• 批准号: 6743124
• 负责人: Luis J Montaner
• 金额: $ 30.99万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743124
• 关键词: AIDS therapy; CD28 molecule; CD40 molecule; HIV infections; RNA directed DNA polymerase; T lymphocyte; clinical research; enzyme activity; human immunodeficiency virus 1; human subject; human therapy evaluation; immunotherapy; interferon gamma; interleukin 12; interleukin 13; macrophage; microorganism immunology; tumor necrosis factor alpha

项目成果

HIV type 1 viremia on ART is positively associated with polyclonal T cell proliferation in subjects with T cell IFN-gamma secretion levels comparable to those of uninfected subjects.

ART 治疗后的 HIV 1 型病毒血症与 T 细胞 IFN-γ 分泌水平与未感染受试者相当的受试者中的多克隆 T 细胞增殖呈正相关。

• DOI: 10.1089/aid.2008.0054
• 发表时间: 2008
• 期刊: AIDS research and human retroviruses
• 影响因子: 1.5
• 作者: Papasavvas,Emmanouil;Moore,ElizabethC;Sun,Junwei;Azzoni,Livio;Pistilli,Maxwell;Mounzer,Karam;Shull,Jane;Kostman,JayR;Montaner,LuisJ
• 通讯作者: Montaner,LuisJ

Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance.

• DOI: 10.4049/jimmunol.0801450
• 发表时间: 2009-04-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Giri MS;Nebozyhn M;Raymond A;Gekonge B;Hancock A;Creer S;Nicols C;Yousef M;Foulkes AS;Mounzer K;Shull J;Silvestri G;Kostman J;Collman RG;Showe L;Montaner LJ
• 通讯作者: Montaner LJ

NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells.

HIV-1 感染的自体 CD4 原代 T 细胞的 NK 细胞裂解：浆细胞样树突状细胞对 IFN 介导的 NK 激活的要求。

• DOI: 10.4049/jimmunol.179.4.2097
• 发表时间: 2007
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Tomescu,Costin;Chehimi,Jihed;Maino,VernonC;Montaner,LuisJ
• 通讯作者: Montaner,LuisJ