Neurocognitive prognosis in survivors of brain tumors

脑肿瘤幸存者的神经认知预后

• 批准号: 6801446
• 负责人: ELANA FARACE
• 金额: $ 13.32万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-16 至 2005-05-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801446
• 关键词: adolescence (12-20); adult human (21+); behavioral /social science research tag; brain neoplasms; clinical research; cognition; human subject; long term survivor; mathematical model; neurologic manifestations; neuropsychological tests; outcomes research; patient oriented research; postoperative state; prognosis; psychological aspect of cancer; quality of life

DESCRIPTION (provided by applicant): Current neuro-oncology research relies on medical outcome measures such as time to tumor progression and survival. However, clarification of the inter-relationships of variables that make up patients' quality of life (QOL), their trajectory over time, and their prognostic value in brain tumors could prove to be superior for decision-making by patients, families, and clinicians. This career development proposal is designed to enhance the Candidate's clinical research skills in the application of multivariate behavioral research methods to the study of QOL and neurocognition in oncology. The Candidate is a fellowship-trained, research-oriented, clinical neuropsychologist, dedicated to a career in patient-oriented, neuropsychological-oncology outcomes research. Strengths of the applicant include interdisciplinary training, a demonstrated ability to engage in programmatic research, experience in clinical service and teaching, and a commitment to the care of patients with malignant brain tumors. Training plan the training will focus on psychological health-outcomes research methodology, behavioral oncology, and observational training in the practice of neurosurgery. The trainee will receive close supervision from experts in psychology, neurosurgery, neuro-oncology, and health evaluation sciences. Specifically, the Candidate will receive training in 1) behavioral health-outcomes research methodology, 2) psycho-oncology and health psychology, and 3) the clinical content of neuro-oncology. In addition, she will receive further training in research ethics, the formation of research collaborations, research presentations, and scientific writing. Research plan the central tenet of the proposed research is that including neuropsychological variables can improve understanding of patients' QOL, elucidate QOL trajectory to end-of-life, and help predict length of survival in malignant brain tumor patient populations. In order to test this proposal, structural equation modeling will be performed to determine inter-relationships of components of QOL, their trajectory over time, and the extent to which QOL predicts patient survival. Environment the University of Virginia, the Department of Neurosurgery, the Cancer Center, and the NeuroOncology Center have outstanding clinical, surgical, and epidemiological resources, and a demonstrated commitment to expanding these assets and supporting the Candidate's research. Results will have implications not only for neuro-oncology, but also for all cancer patients with cognitive impairment, contributing to improved QOL and survivorship for these populations. The ultimate goal is to maximize both survival and QOL.

描述（由申请人提供）：当前的神经肿瘤研究依赖于医疗结果指标，例如时间进行肿瘤进展和生存。 但是，阐明构成患者生活质量（QOL）的变量的相互关系，随着时间的流逝，其轨迹以及对脑肿瘤的预后价值可能会在患者，家庭和临床医生的决策方面表现出色。 该职业发展建议旨在提高候选人在多变量行为研究方法中的临床研究技能中，用于研究肿瘤学中质量和神经认知的研究。 候选人是一名受过奖学金的，面向研究的临床神经心理学家，致力于以患者为导向的，神经心理学的研究成果研究。 申请人的优势包括跨学科培训，有证明参与程序研究的能力，临床服务和教学经验以及对患有恶性脑肿瘤患者的护理的承诺。 培训计划培训将重点关注心理健康状况研究方法，行为肿瘤学和神经外科实践中的观察培训。 学员将受到心理学，神经外科，神经肿瘤和健康评估专家的密切监督。 具体而言，候选人将接受1）行为健康状况研究方法的培训，2）心理肿瘤学和健康心理学，以及3）神经肿瘤学的临床内容。 此外，她将获得进一步的研究道德，研究合作，研究演示和科学写作的培训。 研究计划拟议的研究的中心宗旨是，包括神经心理变量包括可以提高对患者QOL的理解，阐明QOL轨迹到寿命末，并有助于预测恶性脑肿瘤患者人群的生存时间。 为了测试该建议，将进行结构方程建模，以确定QOL组成部分的相互关联，它们的轨迹随着时间的推移以及QOL预测患者存活的程度。 环境弗吉尼亚大学，神经外科系，癌症中心和神经机学中心拥有出色的临床，外科和流行病学资源，并表现出了扩大这些资产并支持候选人研究的承诺。 结果不仅对神经肿瘤学有影响，而且对所有认知障碍的癌症患者也有影响，这有助于改善这些人群的QOL和生存。 最终目标是最大化生存和QoL。