Neurocognitive prognosis in survivors of brain tumors

脑肿瘤幸存者的神经认知预后

基本信息

批准号：
7486721
负责人：
ELANA FARACE
金额：
$ 13.33万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-16 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7486721
关键词：
Affect Age Aging Anxiety Attention Behavioral Behavioral Research Benefits and Risks Biological Tumor Markers Biopsy Brain Brain Neoplasms Cancer Patient Cardiovascular system Cessation of life Clinic Visits Clinical Clinical Research Clinical Services Clinical Trials Cognitive Cognitive aging Collaborations Cox Proportional Hazards Models Daily Data Decision Making Development Diagnosis Disease Disease-Free Survival Drops Educational process of instructing Emotional End Point Enrollment Environment Equation European Organization for Research and Treatment of Cancer Evaluation Excision Factor Analysis Family Fellowship Gamma Knife Radiosurgery Goals Health Health Psychology Impaired cognition Impairment Karnofsky Performance Status Language Length Literature Living Wills Malignant Neoplasms Malignant neoplasm of brain Measures Medical Memory Mental Depression Mental Health Modeling Moods Neurocognition Neurocognitive Newly Diagnosed Numbers Operative Surgical Procedures Outcome Outcome Measure Outcomes Research Palliative Care Patient Care Patients Pattern Performance Personal Satisfaction Personality Population Principal Investigator Progress Review Group Psychology Quality of life Radiation therapy Radiosurgery Rate Recurrence Relative (related person)Reporting Research Research Ethics Research Methodology Research Training Resources Scanning Science Score Self Care Self-control as a personality trait Severities Shapes Social Network Speed Staging Statistical Study Stroke Structure Supervision Survival Analysis Survivors Terminal Disease Testing Time Training United States National Institutes of Health Universities Virginia Visual Writing behavioral health career chemotherapy cognitive function depressive symptoms design end of life experience falls follow-up functional status help-seeking behavior improved motor control neoplastic cell neuro-oncology neuropsychological neurosurgery oncology outcome forecast patient oriented positive mood prognostic programs psychologic psychological distress psychosocial skills social success survivorship theories tumor tumor progression visual performance

Affect Age Aging Anxiety Attention Behavioral Behavioral Research Benefits and Risks Biological Tumor Markers Biopsy Brain Brain Neoplasms Cancer Patient Cardiovascular system Cessation of life Clinic Visits Clinical Clinical Research Clinical Services Clinical Trials Cognitive Cognitive aging Collaborations Cox Proportional Hazards Models Daily Data Decision Making Development Diagnosis Disease Disease-Free Survival Drops Educational process of instructing Emotional End Point Enrollment Environment Equation European Organization for Research and Treatment of Cancer Evaluation Excision Factor Analysis Family Fellowship Gamma Knife Radiosurgery Goals Health Health Psychology Impaired cognition Impairment Karnofsky Performance Status Language Length Literature Living Wills Malignant Neoplasms Malignant neoplasm of brain Measures Medical Memory Mental Depression Mental Health Modeling Moods Neurocognition Neurocognitive Newly Diagnosed Numbers Operative Surgical Procedures Outcome Outcome Measure Outcomes Research Palliative Care Patient Care Patients Pattern Performance Personal Satisfaction Personality Population Principal Investigator Progress Review Group Psychology Quality of life Radiation therapy Radiosurgery Rate Recurrence Relative (related person)Reporting Research Research Ethics Research Methodology Research Training Resources Scanning Science Score Self Care Self-control as a personality trait Severities Shapes Social Network Speed Staging Statistical Study Stroke Structure Supervision Survival Analysis Survivors Terminal Disease Testing Time Training United States National Institutes of Health Universities Virginia Visual Writing behavioral health career chemotherapy cognitive function depressive symptoms design end of life experience falls follow-up functional status help-seeking behavior improved motor control neoplastic cell neuro-oncology neuropsychological neurosurgery oncology outcome forecast patient oriented positive mood prognostic programs psychologic psychological distress psychosocial skills social success survivorship theories tumor tumor progression visual performance

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项目摘要

urrent neuro-oncotogy research relies on medical outcome measures such as time to tumor progression and survival However, clarification of the inter-relationships of variables that make up patients' quality of life (QOL), their trajectory over time, and their prognostic value in brain tumors could prove to be superior for decision-making by patients, families, and clinicians This career development proposal is designed to enhance the Candidate's clinical research skills in the application of multivariate behavioral research methods to the study of QOL and neurocognition in oncology The Candidate is a fellowship-trained, research-oriented, clinical neuropsychologist, dedicated to a career in patient-oriented, neuropsycholcgical- oncology outcomes research Strengths of the applicant include interdisciplinary training, a demonstrated ability to engage in programmatic research, experience in clinical service and teaching, and a commitment to the care of patients with malignant brain tumors Training plan the training will focus on psychological health-outcomes research methodology, behavioral oncology, and observational training in the practice of neurosurgery The trainee will receive close supervision from experts in psychology, neurosurgery, neuro- oncology, and health evaluation sciences Specifically, the Candidate will receive training in 1) behavioral health-outcomes research methodology, 2) psycho-oncology and health psychology, and 3) the clinical content of neuro-oncology In addition, she will receive further training in research ethics, the formation of research collaborations, research presentations, and scientific writing Research plan the central tenet of the proposed research is that including neuropsychological variables can improve understanding of patients' QOL, elucidate QOL trajectory to end-of-life, and help predict length of survival in malignant brain tumor patient populations In order to test this proposal, structural equation modeling will be performed to determine inter-relationships of components of QOL, their trajectory over time, and the extent to which QOL predicts patient survival Environment the University of Virginia, the Department of Neurosurgery, the Cant er Center, and the NeuroOncology Center have outstanding clinical, surgical, and epidemiological resources, and a demonstrated commitment to expanding these assets and supporting the Candidate's research Results will have implications not only for neuro-oncology, but also for all cancer patients with cognitive impairment, contributing to improved QOL and survivorship for these populations The ultimate goal is to maximize both survival and QOL.

urrent神经符合性研究依赖于医学结果指标，例如肿瘤进展的时间然而，生存，阐明了构成患者生活质量的变量的相互关系（QOL），它们随着时间的推移轨迹及其在脑肿瘤中的预后价值可以证明是优越的患者，家庭和临床医生的决策这一职业发展建议旨在增强候选人在应用多元行为研究中的临床研究技能肿瘤学中QOL和神经认知研究的方法是由奖学金培训的，面向研究的，临床神经心理学家，致力于以患者为导向的，神经心理学的职业申请人的肿瘤学成果研究优势包括跨学科培训，这证明了能够从事程序化研究，临床服务和教学经验以及对恶性脑肿瘤训练计划的护理培训将重点放在心理上健康状况研究方法，行为肿瘤学和观察培训在实践中神经外科学员将受到心理学，神经外科，神经外科专家的密切监督肿瘤学和健康评估科学特别是候选人将接受1）行为的培训健康状况研究方法论，2）心理肿瘤和健康心理学，3）临床神经肿瘤学的内容此外，她还将接受进一步的研究道德培训研究合作，研究演示和科学写作研究计划的中心宗旨拟议的研究是，包括神经心理学变量可以改善对患者的理解 QoL，阐明QOL轨迹至寿命，并有助于预测恶性脑肿瘤的生存时间为了测试该建议，患者人群将进行结构方程建模确定QOL组成部分的相互关联，它们的轨迹随着时间的流逝以及QOL的程度预测患者生存环境弗吉尼亚大学神经外科系， CAN CAN中心和神经学中心具有出色的临床，外科和流行病学资源，以及对扩大这些资产并支持候选人的表现的承诺研究结果不仅对神经肿瘤学有影响，而且对所有患有癌症患者认知障碍，有助于改善这些人群的QoL和生存权的最终目标是最大化生存和QOL。