Risk Perception/Communications/Reduction Behaviors

风险认知/沟通/减少行为

基本信息

批准号：
6765050
负责人：
LOIS J LOESCHER
金额：
$ 12.4万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6765050
关键词：
anxiety behavioral /social science research tag cancer prevention cancer risk clinical research communication family structure /dynamics health behavior human subject melanoma method development patient care personnel relations perception psychometrics questionnaires self examination social behavior sunscreens

项目摘要

DESCRIPTION (provided by applicant): Lois J. Loescher, Ph.D., R.N., is a junior investigator involved in cancer genetic risk research at the Arizona Cancer Center (AZCC). A 5-year K07 award will prepare her as an independent investigator to conduct theory-based, behavioral clinical trials with the ultimate goal to decrease cancer incidence/mortality in individuals and families at genetic risk for cancer. Dr. Loescher's previous training in nursing and clinical genetics and her postdoctoral training in psychometric analysis support her ability to move forward from descriptive theory testing to behavioral intervention clinical trials models. The formal training she now needs will target health behavior theories, intrafamily communications theories/models, multi-method analytic approaches (qualitative and quantitative), and will enable her to conduct behavioral trials within cancer-prone families. Dr. Loescher's training will occur at the University of Arizona and several U.S. locations. The AZCC is an NCI-designated comprehensive cancer center with an international reputation for cancer prevention research. Dr. Loescher's sponsors are David S. Alberts, M.D. (AZCC) and Nell D. Weinstein, Ph.D. (Rutgers University) who will mentor her in skin cancer prevention research/clinical trials development and risk perception/communication research, respectively. Additional collaborations with other faculty experts in the targeted training areas provide the intellectual foundation for the K07 experience. Dr. Loescher's research plan focuses on melanoma-prone families and builds on current research programs at the AZCC. No published studies address specific risk processes (defined as perceived risk, intrafamily risk communications, health-care-provider originated risk communications, and risk control actions) in melanoma-prone families. Phase 1 seeks to describe, analyze, and interpret family members' risk processes; and develop a multidimensional instrument to measure of melanoma risk communications. Phase 1 will use rigorously coded qualitative interview data to elicit information about domains of risk communications that can be incorporated into the proposed instrument and used for future behavioral models. Specific aims of Phase 2 are to assess the psychometric properties of measures of melanoma risk processes (defined above) and a related construct, cancer worry. Additionally the relationships of risk process variables and cancer worry will be evaluated in at least 240 patients with melanoma or dysplastic nevi and their first-degree relatives (FDRs). Phase 2 will evaluate differences in risk control behaviors between melanoma/DN patients and FDRs. Results of this research will be used to formulate a model of risk processes and develop future behavioral interventions to reduce cancer risk.

描述（由申请人提供）：Lois J. Loescher，博士，注册护士，是亚利桑那州癌症中心 (AZCC) 从事癌症遗传风险研究的初级研究员。为期 5 年的 K07 奖将使她成为一名独立研究者，开展基于理论的行为临床试验，最终目标是降低具有癌症遗传风险的个人和家庭的癌症发病率/死亡率。 Loescher 博士之前接受的护理和临床遗传学培训以及心理测量分析方面的博士后培训支持她从描述性理论测试转向行为干预临床试验模型的能力。她现在需要的正式培训将针对健康行为理论、家庭内部沟通理论/模型、多方法分析方法（定性和定量），并使她能够在易患癌症的家庭中进行行为试验。 Loescher 博士的培训将在亚利桑那大学和美国多个地点进行。 AZCC是NCI指定的综合性癌症中心，在癌症预防研究方面享有国际声誉。 Loescher 博士的资助者是 David S. Alberts, M.D. (AZCC) 和 Nell D. Weinstein, Ph.D.。（罗格斯大学）将分别指导她进行皮肤癌预防研究/临床试验开发和风险感知/沟通研究。与其他教师专家在目标培训领域的额外合作为 K07 体验奠定了知识基础。 Loescher 博士的研究计划重点关注黑色素瘤易发家庭，并以 AZCC 当前的研究项目为基础。尚未发表的研究涉及黑色素瘤易发家庭的特定风险过程（定义为感知风险、家庭内风险沟通、医疗保健提供者发起的风险沟通和风险控制行动）。第一阶段旨在描述、分析和解释家庭成员的风险过程；并开发多维工具来衡量黑色素瘤风险沟通。第一阶段将使用严格编码的定性访谈数据来获取有关风险沟通领域的信息，这些信息可以纳入拟议的工具中并用于未来的行为模型。第二阶段的具体目标是评估黑色素瘤风险过程（如上所述）和相关概念（癌症担忧）的心理测量特性。此外，还将在至少 240 名黑色素瘤或发育不良痣患者及其一级亲属 (FDR) 中评估风险过程变量和癌症担忧的关系。第二阶段将评估黑色素瘤/DN 患者和 FDR 之间风险控制行为的差异。这项研究的结果将用于制定风险过程模型并开发未来的行为干预措施以降低癌症风险。