PERCEIVED RISK OF INHERITED SUSCEPTIBILITY TO CANCER

感知到的遗传性癌症易感性风险

基本信息

批准号：
2796962
负责人：
LOIS J LOESCHER
金额：
$ 1.57万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-30 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/2796962
关键词：
cancer risk clinical research family genetics human subject neoplasm /cancer genetics oncology nursing

项目摘要

The rapid and continued identification of gene mutations that predisposes people to cancer has led to a better understanding of inherited susceptibility to cancer (ISC). ISC is a high-risk condition for cancer. No studies of risk perception in people with ISC have been published in the nursing literature. No qualitative studies of risk perception in ISC are found in the literature. This proposed research will, therefore, significantly contribute to the overall knowledge base of perceived risk of cancer in adults with ISC. Knowledge of risk perception is important in understanding the decisions people with ISC make concerning genetic testing and strategies for cancer prevention and detection. Once nurses better understand how people with ISC perceive their cancer risk, other critical studies, such as interventions targeting genetic counseling and decision making for genetic testing or studies of nursing care guided by genetic markers of cancer risk, can logically follow. The purpose of this study is to gain understanding of risk perception in ISC. Specific aims are to (1) conduct phenomenology research to identify the essential structure of risk perception in adults with ISC by identifying categories of data and coding data themes for theory building and instrument development; (2) develop a theory-driven preliminary model of perceived risk of cancer in adults with ISC; and (3) develop and test an instrument on the preliminary model to measure risk perception in adults with ISC who are eligible for genetic testing. Qualitative and quantitative approaches will be used for research design and analysis: phenomenology, preliminary model/theory development, and instrumentation.

快速、持续地识别易诱发疾病的基因突变人们对癌症的认识使人们对遗传性有了更好的了解癌症易感性（ISC）。 ISC 是一种癌症高危病症。尚未发表关于 ISC 患者风险感知的研究护理文献。没有对 ISC 中的风险认知进行定性研究是在文献中找到的。因此，这项拟议的研究将对感知风险的整体知识库做出了重大贡献患有 ISC 的成人癌症的发生率。了解风险认知很重要理解 ISC 患者做出的有关遗传的决定癌症预防和检测的测试和策略。曾经的护士更好地了解患有 ISC 的人如何看待他们的癌症风险，其他批判性研究，例如针对遗传咨询和干预的干预措施基因检测或护理研究的决策由以下人员指导癌症风险的遗传标记，可以逻辑地遵循。这样做的目的研究的目的是为了了解 ISC 中的风险认知。具体目标 (1) 进行现象学研究以确定本质通过识别类别来了解 ISC 成人的风险感知结构用于理论构建和工具的数据和编码数据主题发展; (2) 建立一个理论驱动的感知初步模型患有 ISC 的成人患癌症的风险； (3) 开发并测试仪器测量 ISC 成人风险认知的初步模型有资格进行基因检测。定性和定量方法将用于研究设计和分析：现象学、初步模型/理论开发和仪器仪表。