Childhood Precursors to Alcohol Involvement

童年时期酗酒的先兆

• 批准号: 6730096
• 负责人: SUSAN E LUCZAK
• 金额: $ 13.51万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6730096
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; antisocial personality; behavioral /social science research tag; child behavior; clinical research; gender difference; gene expression; genetic susceptibility; genotype; human subject; mathematical model; mental health epidemiology; psychopathology; psychophysiology; substance abuse related behavior

DESCRIPTION (provided by applicant): The primary goal of this five-year career development award is to further develop my expertise in the etiology and measurement of alcohol involvement (use and problems). To reach this immediate career goal, I will receive training in four major domains: (1) the relationship between antisocial and alcohol behavior; (2) the relationship between psychophysiology and alcohol behavior; (3) multivariate methodology for measuring alcohol involvement; and (4) the design and implementation of prospective, longitudinal investigations. The proposed training plan will include the completion of structured coursework and workshops, participation in conferences and interdisciplinary consortiums, and regular mentoring from experts in the alcohol who specialize in methodology, longitudinal research design, and the relationship of psychophysiology, antisocial behavior, and additional forms of psychopathology to alcohol problems. This training builds upon my doctoral training in methodology, my clinical training in psychopathology, and my research background on risk and protective factors for alcohol problems. Ultimately, my long-term career goal is to be a tenure track faculty member in a major research institution examining the etiology of alcohol involvement. The training plan is complemented by a research project designed to prospectively examine childhood risk factors and protective factors for alcohol involvement. Data will be collected on 35 year olds from an original sample of 1,795 participants from the island of Mauritius who have been prospectively followed since age 3 years. Three classes of childhood risk factors (psychophysiology, temperament, and behavior) and three classes of protective factors (variant alcohol metabolizing enzyme alleles, female gender, and Muslim upbringing) are hypothesized to relate to various dimensions of alcohol involvement. Four types of multivariate statistical procedures (multiple and canonical regression, structural equation modeling, and latent class analysis) will be used to assess relationships among precursors and outcome variables. The potential importance of this study regarding the etiology of alcohol problems is large and might eventually help with the development of prevention and treatment programs. This career development award will enable me to transition from an Assistant Research Professor to an independent investigator and will give me the foundation for a research career in the etiology and measurement of dimensions of alcohol involvement.

描述（由申请人提供）：这个五年职业发展奖的主要目标是进一步发展我在酒精参与（使用和问题）的病因学和测量方面的专业知识。 为了实现这个近期的职业目标，我将接受四个主要领域的培训：（1）反社会行为与酗酒行为之间的关系； (2)心理生理学与酒精行为的关系； (3) 测量酒精参与度的多变量方法； (4) 前瞻性、纵向调查的设计和实施。 拟议的培训计划将包括完成结构化课程和研讨会、参加会议和跨学科联盟，以及专门从事方法论、纵向研究设计以及心理生理学、反社会行为和其他形式的关系的酒精专家的定期指导酒精问题的精神病理学。 该培训建立在我的方法论博士培训、精神病理学临床培训以及酒精问题风险和保护因素的研究背景之上。 最终，我的长期职业目标是成为一家主要研究机构的终身教职人员，研究酒精相关的病因学。 该培训计划还辅以一项研究项目，该项目旨在前瞻性地研究儿童酒精参与的危险因素和保护因素。 数据将从来自毛里求斯岛 1,795 名参与者的 35 岁参与者中收集，这些参与者从 3 岁起就被前瞻性地跟踪。 假设三类儿童期危险因素（心理生理、气质和行为）和三类保护因素（酒精代谢酶等位基因变异、女性性别和穆斯林教养）与酒精参与的各个方面有关。 将使用四种类型的多元统计程序（多元和典型回归、结构方程建模和潜在类别分析）来评估前兆和结果变量之间的关系。 这项关于酒精问题病因学的研究具有很大的潜在重要性，最终可能有助于预防和治疗计划的制定。 该职业发展奖将使我能够从助理研究教授转变为独立研究者，并为我在酒精参与的病因学和测量维度方面的研究生涯奠定基础。