Intergenerational Transmission of Alcohol Involvement

酒精参与的代际传播

基本信息

批准号：
8316467
负责人：
SUSAN E LUCZAK
金额：
$ 6.17万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-10 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8316467
关键词：
12 year old 3 year old Accounting Adolescent Affect African Age Alcohol abuse Alcohol consumption Asian Indian Behavioral Biological Child health care Childhood Cognitive Cohort Effect Complex Data Data Set Development Disease Ethnic Origin Ethnic group Exposure to Family Family history of Fathers Female Future Gender Generations Genetic Genetic Risk Harm Reduction Individual Individual Differences Interview Island Joints K-Series Research Career Programs Knowledge Longitudinal Studies Mauritius Measures Mediating Mediation Modeling Mothers Muslim population group Nutritional Parenting behavior Parents Participant Pathway interactions Personality Population Prevalence Prevention Prevention program Principal Investigator Process Prospective Studies Psychophysiology Psychosocial Factor Regulation Reporting Research Risk Risk Factors Role Sampling Sex Characteristics Siblings Spouses Testing Time Woman alcohol behavior alcohol involvement alcohol use initiation cohort contextual factors drinking early drinking ethnic difference grandparent hazardous drinking intergenerational male model development offspring peer psychosocial public health relevance social transmission process

项目摘要

DESCRIPTION (provided by applicant): Individuals with a family history of alcohol problems are at increased risk for developing alcohol problems, but the specific mechanisms by which alcohol behaviors are transmitted from one generation to the next are not well understood. The purpose of the proposed study is to investigate the development of alcohol involvement (i.e. alcohol use and problems) and its intergenerational transmission among participants in the Joint Child Health Project, an ongoing three-generational longitudinal study on the island of Mauritius. In 1972, a general sample cohort of 1,795 male and female 3 year-olds were tested on psycho-physiological, nutritional, cognitive, and temperamental factors, while their first-generation parents were assessed on psychosocial variables. This second generation is now 40 years old and along with their spouses will be assessed on measures of lifetime alcohol involvement and associated genetic, personality, cultural, familial, parenting, and psychosocial measures. The third-generation offspring also have been well characterized on psycho-physiological, nutritional, cognitive, and temperamental factors between the ages of 3 and 11 years. The third-generation offspring who are 12 years of age or older will now be assessed for early alcohol involvement and associated variables, including genetic, familial, peer, cultural, and social influences, personality and individual differences, and psychosocial, cognitive, and behavioral variables. The multigenerational dataset and unique setting of the JCHP will enable us to tease apart the complex interplay of risk and protective factors in ways that cannot be done in U.S. samples where alcohol use is nearly universal. Findings will also test the degree to which pathway models of the development of alcohol problems generalize to a non-Western culture. The three specific aims of the proposed study are: 1) to create a rich dataset for testing mechanisms of alcohol involvement over three generations, 2) to test hypothesized mechanisms for the early initiation of alcohol use in G3 offspring, and 3) to test mechanisms for the progression from initiation to hazardous drinking in G3 offspring. This multigenerational prospective study has sufficient power and comprehensive assessments of childhood precursors and alcohol involvement to disentangle the complex interactive effects of individual differences, psychosocial, biological, cultural, and genetic risk and protective factors on alcohol involvement. Knowledge of such processes will inform future prevention and harm reduction research and efforts. PUBLIC HEALTH RELEVANCE: This study offers a unique opportunity to better understand how biological, cultural, familial, and psychosocial risk and protective factors influence the continuity and change of alcohol involvement across generations. This new knowledge could contribute to more effective prevention programs for reducing alcohol problems and disorders.

描述（由申请人提供）：具有酒精问题家族史的个人患有酒精问题的风险增加，但是对酒精行为从一代传播到另一代的特定机制尚不清楚。拟议的研究的目的是研究酒精参与的发展（即酒精使用和问题）及其在共同儿童健康项目中的参与者之间的代际传播，这是一项在毛里求斯岛进行的一项持续的三代纵向研究。 1972年，对1,795名男性和女性3岁的一般样本队列进行了对心理生理学，营养，认知和气质因素的测试，同时对他们的第一代父母进行了对心理社会变量的评估。第二代已有40年的历史，并将对他们的配偶进行评估，并根据终生酒精参与度以及相关的遗传，人格，文化，家族，育儿和社会心理措施的措施进行评估。第三代后代在3至11岁之间的心理生理，营养，认知和气质因素上也得到了很好的特征。现在将评估12岁或以上的第三代后代，以应对早期酒精参与和相关变量进行评估，包括遗传，家族，同伴，文化和社会影响，个性和个性差异，以及心理社会，认知和行为变量。 JCHP的多代数据集和独特的设置将使我们能够以在饮酒几乎普遍存在的美国样品中无法做到的方式来嘲笑风险和保护因素的复杂相互作用。发现还将测试酒精问题发展的途径模型的程度，将其推广到非西方文化。拟议研究的三个具体目的是：1）创建一个丰富的数据集，用于测试三代人的酒精参与机制，2）测试假设的机制，用于早期在G3后代中饮酒的早期启动，以及3）以测试从G3 Forppring中造成危险饮酒的进展的机制。这项多代前瞻性研究具有对儿童前体和酒精参与的足够的能力和全面评估，以消除个体差异，心理社会，生物学，文化和遗传风险以及保护因素对酒精参与的复杂互动效应。对此类过程的了解将为未来的预防和损害减少研究和努力提供信息。公共卫生相关性：这项研究提供了一个独特的机会，可以更好地了解生物，文化，家庭和社会心理风险以及保护因素如何影响世代相传的酒精参与的连续性和变化。这种新知识可能有助于减少酒精问题和疾病的更有效的预防计划。