Mapping the integration of T cell fate control across time and space

绘制 T 细胞命运控制跨时间和空间的整合图

• 批准号: DP240101851
• 负责人: Prof Sarah Russell
• 金额: $ 45.89万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101851
• 关键词: Mapping; integration; cell; fate; control

This project aims to apply new methods to determine how coordination of signalling complexes impacts upon the fate of cells of the adaptive immune system. It expects to determine how the context of signallng orchestrates cell fates such as differentiation, death and proliferation. The project is expected to yield an experimental and analytical platform for further investigations into a broad range of biological questions, and to provide new knowledge of this fundamental problem. This platform should support further work that ultimately provides new models for tissue and immune cell regeneration, and new manufacturing platforms for therapies for humans and livestock, among other benefits.

该项目旨在采用新方法来确定信号复合物的协调如何影响自适应免疫系统细胞的命运。它希望确定Signallng的背景如何策划细胞命运，例如分化，死亡和增殖。预计该项目将产生一个实验和分析平台，以进一步研究广泛的生物学问题，并提供有关此基本问题的新知识。该平台应支持最终为组织和免疫细胞再生提供新模型的进一步工作，以及针对人类和牲畜疗法的新制造平台，以及其他好处。