Asymmetric cell divison in T cell development: consequences for immunity and cancer

T 细胞发育中的不对称细胞分裂：对免疫和癌症的影响

• 批准号: nhmrc : 1020234
• 负责人: Prof Sarah Russell
• 金额: $ 42.85万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/asymmetric-cell-divison-immunity-cancer/110010
• 关键词: Asymmetric; cell; divison; development; consequences

Human health depends upon the development of an immune system that can effectively control infection without damaging normal tissue. In this project, we assess a new paradigm by which immune cell development might be controlled, in which an immune cell precursor divides in such a way that its two daughters inherit different molecular constitutents that subsequently regulate the adoption of different cell fate. The likely consequences of this phenomonon on immunity and cancer will be explored.

人类健康取决于免疫系统的发展，该系统可以有效控制感染而不损害正常组织。在这个项目中，我们评估了一种可以控制免疫细胞发育的新范式，其中免疫细胞前体以这样的方式分裂，使其两个子细胞继承不同的分子成分，从而调节不同细胞命运的采用。我们将探讨这种现象对免疫和癌症可能产生的后果。