Inorganic nanoparticles for cancer therapy

用于癌症治疗的无机纳米颗粒

• 批准号: 2275454
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2275454
• 关键词: Inorganic; nanoparticles; cancer; therapy

Chemotherapy drugs are known to have widespread side effects. Zinc oxide nanowires have been shown to kill cancer cells without killing healthy equivalents but they degrade too fast in blood. Here, we develop silica nanoparticles containing zinc that can deliver zinc inside cells. The project involves nanoparticle synthesis and characterization, to optimize the zinc delivery. Uptake of the nanoparticles into cells is being investigated, including identifying toxicity ranges and doses in which the nanoparticles can kill breast and bone cancer cells without killing the healthy equivalents.

众所周知，化疗药物具有广泛的副作用。氧化锌纳米线已被证明可以杀死癌细胞而不杀死健康细胞，但它们在血液中降解得太快。在这里，我们开发了含有锌的二氧化硅纳米颗粒，可以将锌输送到细胞内。该项目涉及纳米颗粒的合成和表征，以优化锌的输送。目前正在研究纳米颗粒进入细胞的情况，包括确定纳米颗粒可以杀死乳腺癌和骨癌细胞而不杀死健康细胞的毒性范围和剂量。