ANALYSIS OF STRUCTURE-FROM-MOTION IN VISUAL CORTEX

视觉皮层运动结构分析

基本信息

批准号：
6628642
负责人：
RALPH M SIEGEL
金额：
$ 15.82万
依托单位：
RUTGERS THE STATE UNIV OF NJ NEWARK
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-09-30 至 2005-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6628642
关键词：
Macaca mulatta biological models form /pattern perception motion perception neural information processing visual cortex visual stimulus

项目摘要

DESCRIPTION: (Adapted from the Investigator's Abstract): This proposal undertakes the first systematic analysis of the cortical topography of area 7a of the inferior parietal lobule in the behaving monkey. The focus is on uncovering the distribution of multiple visual, oculomotor and spatial representations across the extent of area 7a. An innovative combination of intrinsic optical imaging, single unit recordings and anatomical tracer methods will be used to address these issues at multiple levels of resolution. Understanding of area 7a in the inferior parietal lobule of the monkey is beginning to plateau. It is well established from single unit studies that area 7a neurons represent visual and eye position information, as well as attentional state. However little is known as to how these properties are distributed across the cortex, or how these distributed representations are modified by behavior. Spatial representations in area 7a: To explore these issues, optic flow (e.g. radial, planar rotational, translation) and luminance stimuli will be presented while the animal fixates on different locations in the visual field in a reaction time task. Many qualities that alter the response of area 7a neurons, such as speed and disparity, and vergence will be systematically manipulated to determine the dependence of the distributed representations. Optical imaging of the intrinsic signal will be used to map the topography of retinal, eye position, and head-centered location across the cortical surface in the behaving monkey. Single unit studies will be used to verify the results of the optical imaging. The relationships between both associational and collosal projections and the optically recorded maps will be determined to verify the maps themselves, as well as to understand how the distributed signals are transmitted to recipient areas. Attentional modulation of maps: The monkeys'attentional state will be altered to determine whether the cortical representation is plastic, i.e. it can be transformed across the cortical surface. The combination of optical measurements, single unit recording, and anatomy allows characterization of normal parietal spatial function. These studies will be crucial in correctly choosing which parietal representations are best modified through therapy when there are spatial deficits in human subjects caused by parietal damage through stroke.

描述：（根据调查员的摘要进行了改编）：此提案对区域7a的皮质地形进行首次系统分析行为猴子中的下顶叶。重点是揭示多个视觉，眼动和空间的分布区域7a范围的表示形式。创新的组合固有的光学成像，单个单位记录和解剖示踪方法将用于以多个分辨率解决这些问题。了解猴子下顶叶中的7a区域是开始高原。它是从单位研究中确定的 7A神经元代表视觉和眼睛位置信息，以及注意状态。但是，对于这些属性的方式鲜为人知分布在皮层上，或这些分布式表示方式通过行为修改。区域7a中的空间表示：探索这些问题，光流（例如径向，平面旋转，翻译）和亮度当动物固定在不同位置的不同位置时，将出现刺激反应时间任务中的视野。改变了许多素质区域7A神经元的反应，例如速度和差异，而Gergence将是系统地操纵以确定分布式的依赖性表示。固有信号的光学成像将用于映射视网膜，眼睛位置和以头为中心的位置的地形行为猴子中的皮质表面。单位研究将用于验证光学成像的结果。两者之间的关系关联和胶萨的预测以及光学记录的地图将是决心验证地图本身，并了解分布式信号传输到受体区域。注意调制地图：将改变猴子的注意状态，以确定是否是否皮质表示是塑料的，即可以在皮质表面。光学测量，单个单元的组合记录和解剖结构允许表征正常的壁空间功能。这些研究对于正确选择哪个顶点至关重要当存在空间时，最好通过治疗来修改表示形式人类受试者的缺陷是由treo中的顶叶损害造成的。