PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITY

早产儿视网膜病变中的光感受器功能

• 批准号: 6635635
• 负责人: ANNE B FULTON
• 金额: $ 35.55万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6635635
• 关键词: clinical research; cone cell; developmental neurobiology; electrophysiology; electroretinography; eye refraction disorder; human subject; infant human (0-1 year); longitudinal human study; medical complication; middle childhood (6-11); myopia; pathologic process; preschool child (1-5); psychophysics; retinopathy of prematurity; rhodopsin; rod cell; visual photoreceptor; visual phototransduction; visual threshold

DESCRIPTION (Applicant's Description): New evidence for photoreceptor involvement before and after resolution of the active, vascular phase of retinopathy of prematurity (ROP) leads to the main hypothesis of this project: the greater the deficit in photoreceptor function the more severe the acute phase ROP. Infants (enrolled at age 10 wks) and children (enrolled at age 8-12 yrs) categorized by severity of ROP (None, Mild Moderate, Severe) will have electroretinographic (ERG) and psychophysical investigations of photoreceptor function. In all subjects, the parameters of the activation of rod phototransduction, and dark-adapted rod thresholds will be measured in parafoveal and peripheral retina. Rod response parameters will be analyzed for significant variation with ROP category. Retinal mechanisms represented in post receptoral responses, and the relationship of receptoral to post-receptoral functions, will also be analyzed. High refractive errors in ROP frequently develop during the years when photoreceptors mature. In this project about retinal mechanisms, the secondary hypothesis is: the greater the photoreceptor dysfunction, the greater the refractive error. All subjects will have cycloplegic refractions, as well as acuities, measured. To evaluate the developing retinal processes and spherical equivalent for causative relations, a longitudinal study of rod thresholds, acuity and refractive error between age 10 wks and 3 yrs will be conducted. The parameters of these courses, as well as the retinal response parameters obtained in the other studies of retinal function, will be used to test the secondary hypothesis. In the children, other photoreceptor functions including deactivation of rod phototransduction, activation of cone phototransduction, and rod increment threshold functions will be investigated. The parameters obtained will be used in further tests of the main and secondary hypotheses, and for within subject evaluation of relative involvement of rods vs. cones, activation vs. deactivation, and receptoral vs. post-receptoral mechanisms. This project, based on an entirely new perspective of ROP, will lead not only to much more information about retinal and visual function in ROP, but also to new knowledge about fundamental ROP disease processes.

描述（申请人的描述）：光感受器的新证据 活动期、血管期消退前后的参与 早产儿视网膜病变 (ROP) 引出了该项目的主要假设： 感光功能缺陷越大，急性症状就越严重 相 ROP。婴儿（10 周岁时注册）和儿童（8-12 岁注册） 年）按 ROP 严重程度分类（无、轻度、中度、严重）将有 光感受器的视网膜电图（ERG）和心理物理学研究 功能。在所有受试者中，杆激活参数 光转导和暗适应杆阈值将在 中心凹旁和周边视网膜。将分析杆响应参数 ROP 类别有显着差异。视网膜机制在后代表 受体反应以及受体与受体后的关系 的功能，也将进行分析。 ROP 经常出现高屈光不正 感光细胞成熟期间发育。在这个项目中关于 视网膜机制，次要假设是：光感受器越大 功能障碍，屈光不正越大。所有科目都会有 测量散瞳屈光度以及视力。评估 发展因果关系的视网膜突起和球面等效物， 年龄间视杆阈值、视力和屈光不正的纵向研究 将进行 10 周和 3 年。这些课程的参数以及 其他视网膜研究中获得的视网膜反应参数 函数，将用于检验第二假设。在儿童中，其他 光感受器功能，包括杆状光转导的失活， 激活视锥光转导和视杆增量阈值功能 将被调查。获得的参数将用于进一步的测试 主要和次要假设，以及主题内评估 视杆细胞与视锥细胞、激活与失活的相对参与，以及 受体机制与受体后机制。该项目完全基于 ROP 的新视角，不仅会带来更多关于 ROP 中的视网膜和视觉功能，而且还涉及有关基础知识的新知识 ROP 疾病过程。