PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITY

早产儿视网膜病变中的光感受器功能

• 批准号: 6518524
• 负责人: ANNE B FULTON
• 金额: $ 35.55万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518524
• 关键词: clinical research; cone cell; developmental neurobiology; electrophysiology; electroretinography; eye refraction disorder; human subject; infant human (0-1 year); longitudinal human study; medical complication; middle childhood (6-11); myopia; pathologic process; preschool child (1-5); psychophysics; retinopathy of prematurity; rhodopsin; rod cell; visual photoreceptor; visual phototransduction; visual threshold

DESCRIPTION (Applicant's Description): New evidence for photoreceptor involvement before and after resolution of the active, vascular phase of retinopathy of prematurity (ROP) leads to the main hypothesis of this project: the greater the deficit in photoreceptor function the more severe the acute phase ROP. Infants (enrolled at age 10 wks) and children (enrolled at age 8-12 yrs) categorized by severity of ROP (None, Mild Moderate, Severe) will have electroretinographic (ERG) and psychophysical investigations of photoreceptor function. In all subjects, the parameters of the activation of rod phototransduction, and dark-adapted rod thresholds will be measured in parafoveal and peripheral retina. Rod response parameters will be analyzed for significant variation with ROP category. Retinal mechanisms represented in post receptoral responses, and the relationship of receptoral to post-receptoral functions, will also be analyzed. High refractive errors in ROP frequently develop during the years when photoreceptors mature. In this project about retinal mechanisms, the secondary hypothesis is: the greater the photoreceptor dysfunction, the greater the refractive error. All subjects will have cycloplegic refractions, as well as acuities, measured. To evaluate the developing retinal processes and spherical equivalent for causative relations, a longitudinal study of rod thresholds, acuity and refractive error between age 10 wks and 3 yrs will be conducted. The parameters of these courses, as well as the retinal response parameters obtained in the other studies of retinal function, will be used to test the secondary hypothesis. In the children, other photoreceptor functions including deactivation of rod phototransduction, activation of cone phototransduction, and rod increment threshold functions will be investigated. The parameters obtained will be used in further tests of the main and secondary hypotheses, and for within subject evaluation of relative involvement of rods vs. cones, activation vs. deactivation, and receptoral vs. post-receptoral mechanisms. This project, based on an entirely new perspective of ROP, will lead not only to much more information about retinal and visual function in ROP, but also to new knowledge about fundamental ROP disease processes.

描述（申请人的描述）：光感受器的新证据 在分辨率之前和之后的参与活性的血管相 早产视网膜病变（ROP）导致该项目的主要假设： 光感受器功能的缺陷越大，急性越严重 相位。婴儿（10周招生）和儿童（在8-12岁时入学 YRS）按ROP的严重程度（无，轻度中，严重）分类 电图（ERG）和心理物理研究感光者 功能。在所有受试者中，杆激活的参数 将测量光转导和深色适应的杆阈值 parafoveal和外围视网膜。将分析ROD响应参数的 与ROP类别的显着变化。邮政中代表的视网膜机制 受体反应以及受体与受体后受体的关系 功能也将进行分析。 ROP中的高折射率很高 在光感受器成熟的几年中发展。在这个项目中 视网膜机理，次要假设是：感光器越大 功能障碍，折射率越大。所有主题都会有 测量了环读折射以及助液。评估 开发视网膜过程和与因果关系的球形等效物 杆阈值，敏锐度和年龄之间的折射率的纵向研究 将进行10周和3年。这些课程的参数以及 在视网膜的其他研究中获得的视网膜反应参数 功能将用于检验次级假设。在孩子们，其他 光感受器功能，包括杆光转导的停用， 锥光转导的激活和杆增量阈值功能 将被调查。获得的参数将用于进一步测试 主要和次要假设，以及在主题评估中 杆与锥体的相对参与，激活与失活，并且 受体与受体后机制。这个项目，完全基于一个 ROP的新观点，不仅会导致有关有关的更多信息 ROP中的视网膜和视觉功能，但也符合有关基本知识的新知识 ROP疾病过程。