The Efficacy of a Mantram Intervention on HIV Outcomes

Mantram 干预对艾滋病毒结果的功效

• 批准号: 6665495
• 负责人: JILL E. BORMANN
• 金额: $ 17.59万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665495
• 关键词: AIDS education /prevention; AIDS therapy; HIV infections; alternative medicine; angers; anxiety; autogenic training; behavior therapy; behavioral /social science research tag; catecholamines; clinical research; coping; cortisol; human subject; human therapy evaluation; hypothalamic pituitary adrenal axis; injury /disease stressor; outcomes research; patient oriented research; quality of life; questionnaires; relaxation; satisfaction; stress management; telemedicine

DESCRIPTION (provided by applicant): This project is a two-year plan to study the efficacy of a mantram (mantra) intervention for interrupting intrusive, stressful thoughts that trigger the stress response in a sample of HIV infected adults. People are living longer with the human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) since the advent of highly active anti-retroviral therapy (HAART). However, there is still no cure. It is well documented that living with HIV/AIDS is stressful and evidence suggests that stress may hasten HIV disease progression by increasing viral replication and suppressing the immune response. Stress management intervention studies in the HAART era have shown improvements in both psychological and physiological measures in H1V infected persons using complex combinations of" cognitive and relaxation therapies. However, no studies have focused on only one intervention or have addressed a spiritual component using a comparable control group to determine which of these interventions is most effective. Epidemiological evidence suggests that spirituality is an important coping resource in HIV/AIDS and is associated with quality of life and well being. A randomized trial (N=60) will be conducted to compare a mantram intervention (n = 30) to an educational control group (n = 30) on primary outcomes of self-reported intrusive thoughts, anxiety, anger, and perceived stress; secondary outcomes of emotion-focused coping, quality of life enjoyment and satisfaction, existential spiritual well being; and tertiary outcomes of salivary cortisol and urinary catecholamines. The intervention will be given over a 10-week period with 5 weekly classes, 4 weekly-automated phone calls, and one final class meeting. Assessments will be conducted at pre-intervention, fifth class midpoint, tenth week post-intervention, and 3-month follow-up. The primary evaluation of intervention efficacy will be conducted using a 2 (group) by 4 (time) mixed ANOVA design with time as a repeated measure. This study is an effort to simplify stress management interventions and to incorporate an element of spirituality, an often-overlooked coping resource for people with HIV. The program is based on a mind-body-spirit philosophy and research on the relaxation response. The study will target both HIV infected men and women, will focus primarily on one intervention technique, and will include a comparable control group for a strong experimental design.

描述（由申请人提供）：该项目是一项为期两年的计划，旨在研究中断侵入性，压力性思想的曼特兰（Mantra）干预措施的疗效，该思想在受HIV感染的成年人样本中触发压力反应。自从高度活跃的抗逆转录病毒疗法（HAART）出现以来，人们使用人类免疫缺陷病毒（HIV）和获得免疫缺陷综合征（AIDS）的人寿命更长。但是，仍然无法治愈。有充分的文献证明，患有艾滋病毒/艾滋病的人压力很大，证据表明，压力可能通过增加病毒复制并抑制免疫反应来加快艾滋病毒疾病的进展。 HAART时代的压力管理干预研究表明，使用“认知和放松疗法的复杂组合”的复杂组合，H1V感染者的心理和生理措施的改善。但是，没有任何研究仅集中在一种干预措施上，或者使用一种可比较的对照组来确定这些干预措施的质量是最重要的。生命和福祉（n = 60）将进行曼特兰干预（n = 30）与自我报告的侵入性思想，焦虑，愤怒和感知的压力的主要结果相比儿茶酚胺将在10周内举行5周的课程，每周4次通话和一个最后一堂课。评估将在干预前，五年级中点，干预后第十周和3个月的随访中进行。干预功效的主要评估将使用2（组）乘4（时间）混合的ANOVA设计与时间作为重复度量进行。 这项研究是为了简化压力管理干预措施并纳入灵性元素，这是艾滋病毒患者经常被忽视的应对资源。该计划基于思维体验哲学和关于放松反应的研究。该研究将针对受艾滋病毒感染的男性和女性，主要集中在一种干预技术上，并将包括一个可比的对照组，以实现强大的实验设计。

项目成果

Living with HIV: responses to a mantram intervention using the critical incident research method.

感染艾滋病毒：使用关键事件研究方法对口头禅干预的反应。

• DOI: 10.1089/acm.2009.0489
• 发表时间: 2012
• 期刊: Journal of alternative and complementary medicine (New York, N.Y.)
• 作者: Kemppainen,Jeanne;Bormann,JillE;Shively,Martha;Kelly,Ann;Becker,Sheryl;Bone,Patricia;Belding,Wendy;Gifford,AllenL
• 通讯作者: Gifford,AllenL