The Efficacy of a Mantram Intervention on HIV Outcomes

Mantram 干预对艾滋病毒结果的功效

• 批准号: 6590660
• 负责人: JILL E. BORMANN
• 金额: $ 17.59万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6590660
• 关键词: AIDS education /prevention; AIDS therapy; HIV infections; alternative medicine; angers; anxiety; autogenic training; behavior therapy; behavioral /social science research tag; catecholamines; clinical research; coping; cortisol; human subject; human therapy evaluation; hypothalamic pituitary adrenal axis; injury /disease stressor; outcomes research; patient oriented research; quality of life; questionnaires; relaxation; satisfaction; stress management; telemedicine

DESCRIPTION (provided by applicant): This project is a two-year plan to study the efficacy of a mantram (mantra) intervention for interrupting intrusive, stressful thoughts that trigger the stress response in a sample of HIV infected adults. People are living longer with the human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) since the advent of highly active anti-retroviral therapy (HAART). However, there is still no cure. It is well documented that living with HIV/AIDS is stressful and evidence suggests that stress may hasten HIV disease progression by increasing viral replication and suppressing the immune response. Stress management intervention studies in the HAART era have shown improvements in both psychological and physiological measures in H1V infected persons using complex combinations of" cognitive and relaxation therapies. However, no studies have focused on only one intervention or have addressed a spiritual component using a comparable control group to determine which of these interventions is most effective. Epidemiological evidence suggests that spirituality is an important coping resource in HIV/AIDS and is associated with quality of life and well being. A randomized trial (N=60) will be conducted to compare a mantram intervention (n = 30) to an educational control group (n = 30) on primary outcomes of self-reported intrusive thoughts, anxiety, anger, and perceived stress; secondary outcomes of emotion-focused coping, quality of life enjoyment and satisfaction, existential spiritual well being; and tertiary outcomes of salivary cortisol and urinary catecholamines. The intervention will be given over a 10-week period with 5 weekly classes, 4 weekly-automated phone calls, and one final class meeting. Assessments will be conducted at pre-intervention, fifth class midpoint, tenth week post-intervention, and 3-month follow-up. The primary evaluation of intervention efficacy will be conducted using a 2 (group) by 4 (time) mixed ANOVA design with time as a repeated measure. This study is an effort to simplify stress management interventions and to incorporate an element of spirituality, an often-overlooked coping resource for people with HIV. The program is based on a mind-body-spirit philosophy and research on the relaxation response. The study will target both HIV infected men and women, will focus primarily on one intervention technique, and will include a comparable control group for a strong experimental design.

描述（由申请人提供）：该项目是一个为期两年的计划，旨在研究咒语（mantra）干预的功效，以打断感染艾滋病毒的成年人样本中引发压力反应的侵入性、压力性想法。自从高效抗逆转录病毒疗法 (HAART) 出现以来，人类免疫缺陷病毒 (HIV) 和获得性免疫缺陷综合症 (AIDS) 患者的寿命变得更长。然而，仍然没有治愈方法。有充分证据表明，艾滋病毒/艾滋病感染者的生活充满压力，并且有证据表明，压力可能会通过增加病毒复制和抑制免疫反应来加速艾滋病毒疾病的进展。 HAART 时代的压力管理干预研究表明，使用认知疗法和放松疗法的复杂组合，H1V 感染者的心理和生理指标均得到改善。然而，没有研究只关注其中一种干预措施，也没有研究使用类似的干预措施来解决精神方面的问题。流行病学证据表明，灵性是艾滋病毒/艾滋病的重要应对资源，并且与生活质量和福祉相关，将进行一项随机试验（N = 60）进行比较。咒语干预(n = 30) 向教育对照组 (n = 30) 介绍自我报告的侵入性想法、焦虑、愤怒和感知压力等主要结果，以及以情绪为中心的应对、生活质量享受和满意度、存在主义精神的次要结果；健康状况；以及唾液皮质醇和尿儿茶酚胺的三级结果 干预将在 10 周内进行，每周 5 次课程，每周 4 次自动电话，最后一次课程。 会议。评估将在干预前、五年级中点、干预后第十周和三个月随访时进行。干预效果的初步评估将使用 2（组）×4（时间）混合方差分析设计进行，并以时间作为重复测量。 这项研究旨在简化压力管理干预措施，并纳入灵性元素，这是艾滋病毒感染者经常被忽视的应对资源。该计划基于身心精神哲学和放松反应研究。该研究将针对艾滋病毒感染者的男性和女性，将主要关注一种干预技术，并将包括一个可比较的对照组以进行强有力的实验设计。