Quantification of Drusen in Macular Degeneration

黄斑变性中玻璃膜疣的量化

• 批准号: 6620653
• 负责人: THOMAS R FRIBERG
• 金额: $ 14.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620653
• 关键词: angiogenesis; biomarker; cataract; clinical research; computer program /software; digital imaging; disease /disorder proneness /risk; eye disorder diagnosis; eye fundus photography; eye laser surgery; human data; longitudinal human study; macular degeneration; macular drusen; nutrition; pathologic process; photocoagulation therapy; vitamins

DESCRIPTION: (Applicant's Abstract) Age-related macular degeneration (AMD) is the most common cause of blindness in the United Sates in Americans over the age of 50. Drusen are by-products of rod and cone metabolism and their presence in the ocular fundus is a clinical sign of AMD. It is known that patients whose eyes harbor drusen are at special risk of visual loss from AMD. In a prospective, multi-centered trial, the Age-Related Eye Disease Study (AREDS), some 5000 patients have been enrolled and followed at six-month intervals to determine risk factors for AMD as well as to measure the influence of certain multivitamins and micronutrients on the progression of macular degeneration and cataract. In another prospective, randomized, controlled trial, the Prophylactic Treatment of AMD Trial (PTAMD), patients with multiple large drusen have been enrolled to determine whether a minimal laser treatment applied one time provides any benefit with respect to lowering rates of visual loss and rates of development of choroidal neovascularization (CNVM). During the PTAMD and AREDS trials, photographs of the fundi of each participant have been taken at least annually in the form of Ektachrome color slides. These slides are evaluated by human readers in a Reading Center and the extent of the drusen is categorized accordingly. The applicant proposes to perform a quantitative analysis on the color slides of the macula of all patients who have been enrolled into the PTAMD and AREDS trials at the Pittsburgh site, as well as other patients who have AMD and have been followed similarly for a minimum of three years. The original slides will be digitized onto CD disks for permanent archiving, and will be analyzed using a specially-written computer algorithm which semi-automatically detects drusen in digital images. Once detected, quantitative measurements of the area of drusen extent and size of each drusen are generated for each image. This method is more precise than characterizing drusen using traditional long and more subjective protocols, and may be valuable in determining the risks of a given patient developing choroidal neovascularization and visual loss before such events occur. That is, such continuous quantitative data may, when analyzed, provide a more accurate and sensitive assessment of risk compared to conventional measurement techniques.

描述：（申请人摘要）年龄相关性黄斑变性（AMD）是 在美国，这是导致美国人失明的最常见原因 50 岁。玻璃疣是视杆细胞和视锥细胞代谢及其存在的副产品 眼底出现异常是AMD的临床症状。据了解，患者 眼睛内有玻璃膜疣的人特别容易因 AMD 而导致视力丧失。在一个 前瞻性、多中心试验，年龄相关眼病研究 (AREDS)， 大约 5000 名患者已入组，并每隔六个月进行一次随访，以 确定 AMD 的风险因素并衡量某些因素的影响 多种维生素和微量营养素对黄斑变性进展的影响 白内障。在另一项前瞻性随机对照试验中， AMD 预防性治疗试验 (PTAMD)，患者患有多个大 玻璃疣已入组以确定是否需要进行最小激光治疗 一次性使用可在降低视觉发生率方面带来任何好处 脉络膜新生血管（CNVM）的损失和发展率。期间 PTAMD 和 AREDS 试验中，每个参与者的眼底照片都有 至少每年以 Ektachrome 彩色幻灯片的形式拍摄一次。这些 幻灯片由阅读中心的人类读者进行评估，并且评估的范围 玻璃疣也相应分类。 申请人建议对彩色切片进行定量分析 已加入 PTAMD 和 AREDS 的所有患者的黄斑 匹兹堡试验中心以及其他患有 AMD 并患有 类似的跟踪至少三年。原始幻灯片将 被数字化到 CD 盘上以进行永久存档，并将使用 一种专门编写的计算机算法，可半自动检测玻璃疣 在数字图像中。一旦检测到，就对其面积进行定量测量 为每个图像生成玻璃疣范围和每个玻璃疣的大小。这个方法 比使用传统的长和更多来表征玻璃疣更精确 主观协议，对于确定给定的风险可能很有价值 在此之前患者出现脉络膜新生血管和视力丧失 事件发生。也就是说，这种连续的定量数据在分析时可能： 与相比，提供更准确、更灵敏的风险评估 传统的测量技术。

项目成果

Computerized detection and measurement of drusen in age-related macular degeneration.

年龄相关性黄斑变性中玻璃疣的计算机化检测和测量。

• DOI: 10.3928/15428877-20070301-07
• 发表时间: 2007
• 期刊: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
• 作者: Friberg,ThomasR;Huang,Linda;Palaiou,Maria;Bremer,Rob
• 通讯作者: Bremer,Rob