Quantification of Drusen in Macular Degeneration

黄斑变性中玻璃膜疣的量化

• 批准号: 6420119
• 负责人: THOMAS R FRIBERG
• 金额: $ 14.97万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420119
• 关键词: angiogenesis; biomarker; cataract; clinical research; computer program /software; digital imaging; disease /disorder proneness /risk; eye disorder diagnosis; eye fundus photography; eye laser surgery; human data; longitudinal human study; macular degeneration; macular drusen; nutrition; pathologic process; photocoagulation therapy; vitamins

DESCRIPTION: (Applicant's Abstract) Age-related macular degeneration (AMD) is the most common cause of blindness in the United Sates in Americans over the age of 50. Drusen are by-products of rod and cone metabolism and their presence in the ocular fundus is a clinical sign of AMD. It is known that patients whose eyes harbor drusen are at special risk of visual loss from AMD. In a prospective, multi-centered trial, the Age-Related Eye Disease Study (AREDS), some 5000 patients have been enrolled and followed at six-month intervals to determine risk factors for AMD as well as to measure the influence of certain multivitamins and micronutrients on the progression of macular degeneration and cataract. In another prospective, randomized, controlled trial, the Prophylactic Treatment of AMD Trial (PTAMD), patients with multiple large drusen have been enrolled to determine whether a minimal laser treatment applied one time provides any benefit with respect to lowering rates of visual loss and rates of development of choroidal neovascularization (CNVM). During the PTAMD and AREDS trials, photographs of the fundi of each participant have been taken at least annually in the form of Ektachrome color slides. These slides are evaluated by human readers in a Reading Center and the extent of the drusen is categorized accordingly. The applicant proposes to perform a quantitative analysis on the color slides of the macula of all patients who have been enrolled into the PTAMD and AREDS trials at the Pittsburgh site, as well as other patients who have AMD and have been followed similarly for a minimum of three years. The original slides will be digitized onto CD disks for permanent archiving, and will be analyzed using a specially-written computer algorithm which semi-automatically detects drusen in digital images. Once detected, quantitative measurements of the area of drusen extent and size of each drusen are generated for each image. This method is more precise than characterizing drusen using traditional long and more subjective protocols, and may be valuable in determining the risks of a given patient developing choroidal neovascularization and visual loss before such events occur. That is, such continuous quantitative data may, when analyzed, provide a more accurate and sensitive assessment of risk compared to conventional measurement techniques.

描述：（申请人的摘要）与年龄相关的黄斑变性（AMD）为 美国人在美国人中最常见的失明原因 50岁。杜鲁森是杆和锥代谢的副产品及其存在 在眼底，眼底是AMD的临床标志。众所周知，患者的患者 Eyes Harbour Drusen有AMD视觉丧失的特殊风险。在 与年龄相关的眼病研究（AREDS）的前瞻性，以上为中心的试验， 约有5000名患者已入学，并以六个月的间隔紧随其后 确定AMD的危险因素，并衡量某些的影响 多种维生素和微量营养素关于黄斑变性的进展 白内障。在另一个前瞻性，随机，对照试验中 预防性治疗AMD试验（PTAMD），多个大型患者 DRUSEN已被招募以确定最小的激光处理 一次应用可为降低视觉率提供任何好处 脉络膜新血管形成（CNVM）的损失和发育率。期间 PTAMD和AREDS试验，每个参与者的基金会的照片 至少每年以ektachrome颜色幻灯片的形式采用。这些 幻灯片由阅读中心的人类读者评估 德鲁森被归类。 申请人建议对彩色幻灯片进行定量分析 所有已入学到PTAMD和ARED的患者的黄斑 匹兹堡现场的试验以及其他患有AMD且具有的患者 紧随其后至少三年。原始幻灯片将 将其数字化到CD磁盘上以进行永久存档，并将使用 半自动检测DRUSEN的专门编写的计算机算法 在数字图像中。一旦检测到该面积的定量测量 每个图像都会生成每个drusen的drusen范围和大小。此方法 比使用传统的长时间表征drusen更精确 主观协议，并且对于确定给定的风险可能很有价值 在此之前，患者发展脉络膜新生血管和视觉丧失 发生事件。也就是说，在分析时，这种连续的定量数据可能会 与 常规测量技术。