Objective Assessment of Suppression in Amblyopia

弱视抑制的客观评估

• 批准号: 6653071
• 负责人: Suzanne P McKee
• 金额: $ 17.06万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653071
• 关键词: amblyopia; behavioral /social science research tag; binocular vision; child (0-11); clinical research; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; electroencephalography; evoked potentials; human subject; neural information processing; noninvasive diagnosis; psychophysics; suppression; vision tests; visual perception; visual stimulus

DESCRIPTION (provided by applicant): We will design an objective test, based on the Visual Evoked Potential (VEP), to measure amblyopic suppression. Our basic tool is the VEP monocular response to periodic vernier onset/offset transitions in bar stimuli, and its suppression during dichoptic stimulation with matching contours. What is unique about this approach is that it identifies which eye is being suppressed as well as the visual acuity of each eye. Although we will develop and validate this test in adult subjects, our dichoptic visual display system has been specifically designed for ultimate use with infants and pre-verbal children. We also will use a new multi-channel recording system (Geodesic Sensor Net) to explore the neural basis for the differences between normal and abnormal binocular processing. About 4% of all children suffer from strabismus and/or anisometropia during early development. These abnormalities place an individual at risk for a variety of visual deficiencies. The most serious outcome is amblyopia in one eye. Amblyopia refers to a loss of visual acuity, without obvious organic cause, that cannot be corrected by wearing spectacles or contact lenses. Perhaps one third of strabismics and anisometropes suffer some loss in visual acuity. The proposed test could assist with the diagnosis of amblyopia in infancy, as well as in monitoring progress during treatment, thereby improving the chance of a favorable outcome.

描述（由申请人提供）：我们将根据视觉诱发电位（VEP）设计客观测试，以测量弱点抑制。我们的基本工具是对条形刺激中周期性游标发作/偏移过渡的VEP单眼响应，及其在与匹配轮廓的二分法刺激过程中的抑制。这种方法的独特之处在于，它可以识别受抑制的眼睛以及每只眼睛的视力。尽管我们将在成人受试者中开发和验证这项测试，但我们的二分光视觉显示系统是专门设计的，旨在与婴儿和言语前儿童最终使用。我们还将使用新的多通道记录系统（地球传感器网）来探索正常和异常双眼处理之间差异的神经基础。在早期发育期间，所有儿童中约有4％的儿童患有斜视和/或苯甲酸。这些异常使个人有各种视觉缺陷的风险。最严重的结果是一只眼睛的弱视。弱视是指视力丧失，而没有明显的有机原因，这无法通过佩戴眼镜或隐形眼镜来纠正。也许有三分之一的斜视和肛门图的视力损失。拟议的测试可以帮助诊断婴儿期弱视，以及在治疗过程中监测进度，从而提高结果的机会。