IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAINING

免疫血液学/输血医学研究培训

基本信息

批准号：
6627492
负责人：
Brian Richard Smith
金额：
$ 11.79万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-08-01 至 2006-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6627492
关键词：
IMMUNOHEMATOLOGY TRANSFUSION MEDICINE RESEARCH TRAINING

项目摘要

(Applicant's Abstract) We propose to establish an NIH-supported research training program in Immunohematology and Transfusion Medicine designed to take MDs and MD/PhDs, who have fully completed their clinical training in these disciplines, and provide them with the tools to become productive physician-scientists with an abiding interest in basic science and translational research in these relatively underrepresented investigative areas. We believe that these biomedical scientists should be trained in an environment that emphasizes basic biological processes and which simultaneously provides continuous didactic exposure to those state-of-the-art investigative issues which are relatively unique to immunohernatology and transfusion medicine, e.g., transfusion-induced immunomodulation, cellular alteration and apoptosis during ex vivo storage, cell engineering pretransfusion, and allo- and auto- immunity to circulating cells and plasma proteins. Our interdisciplinary and multi-departmental faculty include 21 investigators (19 senior and 2 junior, including MDs, MD/PhDs and PhDs) who have a long history of collaborative publications, trainees and grants and whose laboratories are very experienced in the simultaneous training of post-doctoral PhDs, post doctoral MDs and pre-doctoral PhD candidates. We have the educational philosophy that trainees in this program must have their core experience at the bench, that they require carefully crafted training and career guidance by an individualized trainee committee somewhat analogous to a pre-doctoral thesis committee, and that we must provide ongoing venues for them to interact on a one-to-one basis with additional internationally recognized investigator's in immunohematology and transfusion who are from other institutions. In the 1st year of the grant we are requesting support for one post-doctoral position and thereafter for support of 2 post-doctoral positions each year. We expect that MD trainees will require 2-3 years of training at this level before moving to a K-award equivalent and MD/PhDs 1-2 years with one new trainee added to the program each year. We have had past successful experience training exactly the same type of individuals we propose for this T32 but using mechanisms of support other than a T32 (individual NRSAs, research fellowships from foundations and the like). Those individuals have all gone on to successful academic careers. We believe strongly that an institutional T32 would provide a markedly enhanced, coordinated and formalized training experience for this type of clinician-scientist and provide a smoother pathway for these individuals to move to the next level of independence and eventually comprise the next generation of clinician-scientists who can bridge the gap between fundamental research and clinical need in immunohematology and transfusion.

（申请人摘要）我们建议在 NIH 支持的研究培训计划中建立免疫血液学和输血医学旨在攻读医学博士和医学博士/博士学位，已完全完成这些学科的临床培训，并且为他们提供成为富有成效的医师科学家的工具对这些领域的基础科学和转化研究有持久的兴趣代表性相对不足的调查领域。我们相信，这些生物医学科学家应该在强调的环境中接受培训基本的生物过程，同时提供连续的对那些最先进的调查问题的教学接触免疫血液学和输血医学相对独特，例如，输血诱导的免疫调节、细胞改变和细胞凋亡离体储存、细胞工程预输血以及同种免疫和自身免疫循环细胞和血浆蛋白。我们的跨学科和多部门教职人员包括 21 名研究人员（19 名高级研究人员和 2 名初级研究人员）包括医学博士、医学博士/博士和博士学位），他们具有悠久的合作历史出版物、受训人员和资助，其实验室经验丰富博士后博士、博士后医学博士和博士后同步培养博士前博士生。我们的教育理念是让学员在这个计划中，他们必须在替补席上拥有核心经验，他们需要个性化的精心设计的培训和职业指导实习生委员会有点类似于博士前论文委员会，以及我们必须为他们提供一对一互动的持续场所以及其他国际公认的免疫血液学研究人员以及来自其他机构的输血者。在补助金的第一年我们正在请求支持一个博士后职位，然后再请求支持每年支持2个博士后岗位。我们期望 MD 实习生在升级到 K-award 之前，需要接受 2-3 年的该级别培训同等学历和医学博士/博士学位 1-2 年，并在该计划中添加一名新学员每年。我们过去有过成功的培训经验一模一样我们为此 T32 提议但使用支持机制的个人类型除了 T32（个人 NRSA、基金会的研究奖学金和之类的）。这些人都取得了成功的学术生涯。我们坚信机构 T32 将提供显着的针对此类人员的强化、协调和正规化培训经验临床医生-科学家，并为这些人提供更顺畅的途径进入下一个独立水平并最终组成下一个独立水平一代临床医生科学家能够弥合基础知识之间的差距免疫血液学和输血方面的研究和临床需求。