Research Training in Inherited Neurological Disease

遗传性神经疾病研究培训

• 批准号: 6604958
• 负责人: MARK LEPPERT
• 金额: $ 16.69万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6604958
• 关键词: Research; Training; Inherited; Neurological; Disease

DESCRIPTION (provided by applicant) This is a revised application for a grant to create a program in Research Training in Inherited Neurologic Diseases at the University of Utah. Nineteen faculty members serve as research preceptors for trainees, and the faculty consists of both physician-scientists and basic scientists. Research groups participating in the Training Program include the Neuromuscular Division (Dept. of Neurology); the Division of Medical Genetics (Dept. of Pediatrics); and the Departments of Human Genetics, Neurobiology and Anatomy, and Ophthalmology. Areas represented include genetics of movement disorders, genetics of demyelinating disorders, studies of virally-mediated gene transfer, and targeted gene disruption through homologous recombination. Research opportunities for trainees include exposure to large kindreds for linkage mapping and genotype/phenotype correlation studies, and exposure to modern techniques of molecular biology, genetic epidemiology, linkage analysis, and genomic analysis. A plan is presented for a highly focused two-year postdoctoral training program, with a didactic curriculum as part of the first year which will provide the trainee with the necessary background and knowledge base for clinical research. This application requests support for one physician-scientist post-doctoral trainee in the first year, and two trainees in each of the subsequent years. In addition, in response to comments in the previous review, funding support is requested for two predoctoral candidates per year, to be competitively selected from trainees within the University's multidisciplinary Neuroscience and Molecular Biology programs.

描述（由申请人提供） 这是一份修改后的拨款申请，用于创建研究项目 犹他大学遗传性神经系统疾病培训。十九 教职人员担任受训者的研究导师，教职人员 由医师科学家和基础科学家组成。研究小组 参加培训计划的包括神经肌肉科（Dept. 神经病学）；医学遗传学科（儿科）；和 人类遗传学、神经生物学和解剖学以及眼科系。 代表领域包括运动障碍遗传学、 脱髓鞘疾病、病毒介导的基因转移研究，以及 通过同源重组靶向基因破坏。研究 受训者的机会包括接触大家族以建立联系 绘图和基因型/表型相关性研究，以及接触现代 分子生物学、遗传流行病学、连锁分析技术 基因组分析。 提出了为期两年的高度集中的博士后培训计划 计划，第一年的教学课程将 为学员提供必要的背景和知识基础 临床研究。此应用程序请求支持一个 第一年的医师科学家博士后实习生，以及两名实习生 在随后的每一年。另外，针对评论中的评论 先前审查，为两名博士前候选人请求资金支持 每年，从大学范围内的实习生中竞争性地选拔 多学科神经科学和分子生物学项目。