VIRAL LOCALIZATION BY IN SITU HYBRIDIZATION

通过原位杂交进行病毒定位

• 批准号: 6591335
• 负责人: MEREDITH A SIMON
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6591335
• 关键词: AIDS; Mammalia; animal tissue; cardiovascular system; communicable diseases; immunology; inflammation; lymphatic system; nervous system; respiratory system; virus

Rhesus monkeys (M mulatta) infected with the lentivirus, SIV, develop an immunodeficiency syndrome with marked similarities to HIV infection in humans Approximately 70% of experimentally SIV-infected animals succumb to AIDS within one year, although the disease varies with virus strain, and the immune response of the host We are using in situ hybridization with probes to SIV, SRV-1, CMV, EBV, Herpes saimiri, parvovirus, and SV40 to study tissue localization in primary retroviral- induced lesions and lesions induced by opportunistic infections in macaques experimentally infected with different strains of SIV

感染了慢病毒，SIV的恒河猴（M Mulatta） 发展与HIV明显相似的免疫缺陷综合征 人类感染大约70％的实验SIV感染 动物在一年内屈服于艾滋病，尽管疾病有所不同 使用病毒菌株以及我们正在使用的宿主的免疫反应 与SIV，SRV-1，CMV，EBV，疱疹的探针的原位杂交 Saimiri，细小病毒和SV40用于研究原发性组织的组织定位 逆转录病毒诱导的病变和病变由机会性诱导 猕猴的感染实验感染了不同的菌株 Siv