DIAGNOSTIC & CLINICAL PATHOLOGY

诊断

• 批准号: 6116519
• 负责人: MEREDITH A SIMON
• 金额: $ 14.02万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116519
• 关键词: Mammalia; animal tissue; communicable diseases; hematology; immunology; infant mortality; inflammation; low birth weight infant human

The Division of Comparative Pathology provides anatomic and clinical pathology services to the various Divisions of the Center, affiliated scientists, collaborative scientists and other scientific investigators from the New England area who utilize the resources of this Center The number of requisitions for these services can be categorized as follows a Number of post-mortem examinations performed 401 b Number of biopsy specimens processed and examined 277 c Number of complete blood counts (CBCs) 3950 d Number of other clinical pathology requisitions including fecal examinations, chemistry analyses, urinalyses, cytological examinations, and fluid analyses 915 e Number of specimens collected for outside investigators 151 Complete postmortem and histopathologic examinations were performed on all nonhuman primates that died at the Center including abortuses and stillbirths from the several breeding colonies, animals dying of spontaneous disease while not involved in a research project, and those animals that died or were sacrificed while on specific studies The data generated from examination of those tissues is used to monitor outbreaks of infectious diseases in our colony, to provide ancillary support for ongoing research studies, and to provide diagnostic support to our clinical veterinary staff Finally, the diagnostic laboratory is fundamental in the recognition of certain natural diseases of captive nonhuman primates that may be explored as models of certain human diseases states Examples of these recognized and characterized previously at the Center include simian AIDS, colitis and colonic carcinoma, and glomerulonephritis Very active and large studies on the pathogenesis of AIDS are ongoing at the present time within the Division of Comparative Pathology, resulting from these initial observations and descriptions Further characterization of more recently described conditions of nonhuman primates are under investigation, including arteriopathy in SIV-infected Macaca mulatta, adenovirus infection in infant SIV-infected Macaca mulatta, and Pneumocystis carinii infection in SIV-infected macaques Publications Chalifoux LV, MacKey J, Carville A, Shvetz D, Lin KC, Lackner A, Mansfield KG Ultrastructural morphology of Enterocytozoon bieneusi in biliary epithelium of rhesus macaques (Macaca mulatta) Vet Pathol 35:292-296, 1998

比较病理的分裂提供了解剖学和 为中心的各个部门提供临床病理服务， 附属科学家，合作科学家和其他科学家 来自新英格兰地区的调查人员利用 该中心这些服务的申请数量可能是 分类如下如下 401 b处理和检查的活检标本数量277 C数字 全血数（CBC）3950 d其他临床数量 病理申请，包括粪便检查，化学 分析，尿液学，细胞学检查和流体分析915 e为外部调查人员收集的标本数量151完成 对所有人进行了验尸和组织病理学检查 非人类灵长类动物在中心死亡，包括堕胎和 来自几个繁殖菌落的死胎，死亡的动物 自发疾病尽管不参与研究项目，并且 那些在特定研究中死亡或被牺牲的动物 这些组织检查产生的数据用于 监测我们殖民地中传染病的暴发，以提供 辅助支持正在进行的研究，并提供 最终，对我们的临床兽医人员的诊断支持， 诊断实验室对某些人的识别至关重要 可以探讨的圈养非人类灵长类动物的自然疾病 某些人类疾病的模型指出了这些公认的例子 并以前在中心进行的特征包括Simian Aids， 结肠炎和结肠癌，肾小球肾炎非常活跃，并且 目前正在进行有关艾滋病发病机理的大型研究 比较病理学的时间内的时间 这些最初的观察和描述进一步表征 最近描述的非人类灵长类动物的条件在 调查，包括SIV感染的Macaca Mulatta中的动脉炎， 婴儿SIV感染的Macaca Mulatta中的腺病毒感染，以及 SIV感染的猕猴出版物中的肺炎藻藻症感染 Chalifoux LV，Mackey J，Carville A，Shvetz D，Lin KC，Lackner A， Mansfield kg肠肠肠Bieneusi的超微结构形态 恒河猕猴（Macaca Mulatta）兽医Pathol的胆道上皮 35：292-296，1998