CRYSTALLOGRAPHIC STUDIES OF IRON DEPENDENT REPRESSOR FROM M TUBERCULOSIS

结核分枝杆菌铁依赖性抑制子的晶体学研究

• 批准号: 6586723
• 负责人: EHMKE POHL
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586723
• 关键词: bacteria; bioimaging /biomedical imaging; biomaterials; biomedical resource; proteins; radiography; structural biology

Adenine phosphoribosyltransferase (APRT) is a purine salvage enzyme that catalyzes the transfer of ribose-5-phosphate to adenine, creating AMP and pyrophosphate. Although mammals synthesize purines de novo, parasitic protozoa must scavenge purines from their host. Rapidly dividing cancer cells also rely heavily on the purine salvage pathway for their purine source. APRT is an important enzyme enabling parasites and tumor cells to recycle host purines, and for that reason, it is a promising target for drugs aimed at treating cancers and parasitic infections.

腺嘌呤磷脂基转移酶（APRT）是嘌呤挽救 催化5-磷酸核糖向腺嘌呤转移的酶， 创建AMP和焦磷酸盐。 虽然哺乳动物合成嘌呤 从头开始，寄生原生动物必须从宿主那里清除嘌呤。 迅速分裂的癌细胞也很大程度上依赖于嘌呤的抢救 他们的嘌呤来源的途径。 APRT是一个重要的酶 寄生虫和肿瘤细胞回收寄生的嘌呤，为此 原因，这是旨在治疗癌症的药物的有希望的目标 和寄生虫感染。