Functional Organization of the Auditory Cortex

听觉皮层的功能组织

• 批准号: 6634510
• 负责人: TROY A. HACKETT
• 金额: $ 26.43万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634510
• 关键词: Callithricidae; Macaca; Pan; auditory cortex; brain mapping; electrophysiology; human tissue; mesencephalon; neural information processing; neuroanatomy; neurophysiology; thalamus

DESCRIPTION: (Adapted from applicant's abstract): We have proposed that the primate auditory cortex is organized into three major regions: a core region of three primary-like areas, a belt region containing seven or eight areas bordering the core laterally and medially, and a parabelt region that has at least two subdivisions. Each region represents a successive level of processing, and subdivisions within each region are activated by parallel inputs. The first specific aim is directed at one of the most tentative aspects of this model, which suggests that the medial and lateral portions of the belt region are functionally-distinct. Patterns of cortical and subcortical connections differ between these two regions, and there is compelling electrophysiological evidence of auditory and somatosensory convergence in at least part of the medial belt. We will test the hypothesis that the medial and lateral belt regions mediate different aspects of auditory processing in experiments designed to determine the functional organization of individual fields. Multiunit recordings will be used to identify receptive field properties of neuronal clusters, topographic patterns, and boundaries between subdivisions. These data will guide the placement of neuronal tracers within individual fields to reveal cortical and subcortical connections. The anatomical and physiological data will be combined into functional profiles of each area to evaluate their contributions to auditory cortical processing, in general, and signficance with respect to the general hypothesis. A related issue concerns the extent to which the basic principles of auditory cortical organization in monkeys can be generalized to humans. As a second aim, we will compare architectonic features of auditory cortex in nonhuman primates and humans. Analyses of cytoarchitecture, myeloarchitecture, and the distribution of acetyicholinesterase, cytochrome oxidase, parvalbumin, calbindin, SMI-32, and CAT-301 will be combined to characterize and compare the architecture of core, belt, and parabelt fields in the auditory cortex of monkeys, apes, and humans. As suggested by functional studies in humans and nonhuman primates, we expect to find similarities across species, but important differences may exist that relate to functional specializations. Advancing our understanding of basic auditory cortical organization and processing is essential for continued efforts to evaluate the effects of pathology on auditory function, the capacity for recovery after injury, and the effeSECONDARY

描述：（改编自申请人的摘要）：我们提出了 灵长类的听觉皮层分为三个主要区域： 三个主要区域，一个带有七个或八个区域的皮带区域 在侧面和内侧与核心接壤 至少有两个细分。每个区域代表连续的水平 处理和每个区域内的细分都通过并行激活 输入。第一个具体目标是针对最试验的方面之一 该模型，这表明皮带的内侧和外侧部分 区域在功能上存在。皮质和皮质下的模式 这两个区域之间的联系有所不同，并且有令人信服的 AT的听觉和体感收敛的电生理证据 内侧最少的一部分。我们将测试中间和 外侧带区域介导听觉处理的不同方面 旨在确定个体功能组织的实验 字段。多单元记录将用于识别接受场 神经元簇，地形图案和边界的特性 细分。这些数据将指导神经元示踪剂的位置 单个领域揭示皮质和皮层接触。这 解剖学和生理数据将合并为 每个领域评估他们对听觉皮层处理的贡献， 一般和关于一般假设的迹象。 一个相关的问题涉及听觉基本原理的程度 可以将猴子的皮质组织推广到人类。作为第二个目标， 我们将比较非人类灵长类动物中听觉皮层的建筑特征 和人类。细胞结构，骨髓结构和分析 乙酸酯酶，细胞色素氧化酶，白蛋白，白蛋白的分布 Calbindin，SMI-32和Cat-301将合并以表征和比较 核心，皮带和偏对片的建筑在听觉皮层中 猴子，猿猴和人类。正如人类功能研究所暗示的那样 非人类灵长类动物，我们希望在物种之间找到相似之处，但很重要 可能存在与功能专业有关的差异。推进我们 了解基本听觉皮层组织和处理是 继续努力评估病理对的影响至关重要 听觉功能，受伤后的恢复能力以及 effesecmondary