Trauma and PTSD in Substance Abuse Treatment

药物滥用治疗中的创伤和创伤后应激障碍

• 批准号: 6679920
• 负责人: JESSICA M PEIRCE
• 金额: $ 12.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-10 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6679920
• 关键词: behavioral /social science research tag; clinical research; comorbidity; drug abuse therapy; gender difference; health behavior; health care service utilization; health services research tag; human subject; intravenous drug abuse; patient oriented research; posttraumatic stress disorder; substance abuse related behavior; trauma

DESCRIPTION (provided by applicant): This proposal is a NIH-NIDA application for a Mentored Patient-Oriented Research Career Development Award (K23) for Jessica Peirce, Ph.D. The proposed work will take place in an impressive academic and clinical environment and the excellent mentoring team will be led by Dr. R. K. Brooner, a widely-respected clinician and drug abuse treatment researcher. His expertise in psychiatric comorbidity, associations between comorbidity and drug abuse treatment and in the development of novel treatment approaches is exceptionally well-suited to my career goals. The co-mentors provide critical scope and depth to the team. Dr. Stitzer is an internationally recognized expert in the behavioral treatment of drug abuse and an accomplished writer and research mentor. Dr. Svikis is a respected drug abuse researcher with an expertise in the assessment and treatment of women. The career development plan involves three integrated and temporally overlapping areas of work. Component one involves completion of an organized series of JHU academic courses on the development and conduct of clinical trials involving human subjects. The second component involves implementation and conduct of three studies of drug abusers. These studies address four interrelated questions on psychiatric comorbidity, drug abuse treatment-seeking and drug abuse treatment response in women versus men: 1) what are the best strategies for assessing trauma exposure and Posttraumatic Stress Disorder (PTSD)?; 2) what is the role of trauma and PTSD in treatment-seeking?; 3) what is the role of trauma and PTSD in response to routine drug abuse treatment?; and 4) how do gender and gender-related characteristics relate to trauma and PTSD and to drug abuse treatment-seeking and response? Study 1 evaluates two procedures for assessing traumatic event exposure and PTSD, both of which are used clinically but have not been systematically studied. Study 2 evaluates the effect of previous and ongoing traumatic event exposure and PTSD on drug abuse treatment-seeking. Study 3 evaluates the impact of prior and ongoing traumatic event exposure and PTSD on response to routine drug abuse treatment interventions. Interactions with gender and gender specific characteristics will be systematically investigated in each study. The third component will be marked by the submission of an R01 or similar type of grant to evaluate interventions to reduce the negative impact of pre-treatment and in-treatment characteristics in women and men and improve treatment-seeking and drug abuse treatment response. Accomplishing these three goals will document my progression to an independent patient-oriented researcher and recognized expert in the assessment and treatment of drug abusing women and men with PTSD and other comorbid disorders.

描述（由申请人提供）： 该提案是NIH-NIDA申请，授予杰西卡·皮尔斯（Jessica Peirce）博士的指导患者研究职业发展奖（K23）。拟议的工作将在令人印象深刻的学术和临床环境中进行，优秀的指导团队将由广泛尊敬的临床医生和药物滥用治疗研究员R. K. Brooner博士领导。他在精神病合并症，合并症与滥用药物治疗之间的关联以及新颖治疗方法的发展非常适合我的职业目标非常适合。委托人为团队提供关键的范围和深度。 Stitzer博士是国际公认的药物滥用行为治疗的专家，也是一位出色的作家和研究导师。 Svikis博士是一位受人尊敬的药物滥用研究人员，在评估和治疗妇女方面具有专业知识。职业发展计划涉及三个综合和时间重叠的工作领域。组成部分涉及完成一系列有组织的JHU学术课程，以开发和进行涉及人类受试者的临床试验。第二个组成部分涉及实施和进行三项滥用药物的研究。这些研究涉及四个有关精神病合并症，滥用药物治疗和药物滥用治疗反应的问题：1）评估创伤暴露和创伤后应激障碍（PTSD）的最佳策略是什么？ 2）创伤和PTSD在寻求治疗中的作用是什么？ 3）创伤和PTSD对常规药物滥用治疗的作用是什么？ 4）与性别和性别相关的特征与创伤和PTSD以及滥用药物治疗治疗和反应有何关系？研究1评估了评估创伤事件暴露和PTSD的两种程序，两者在临床上使用，但尚未系统地研究。研究2评估了以前和正在进行的创伤事件暴露和PTSD对寻求药物治疗的影响。研究3评估了先前和正在进行的创伤事件暴露和PTSD对常规药物滥用治疗干预措施的影响。在每项研究中将系统地研究与性别和性别特定特征的相互作用。第三个组成部分将以R01或类似类型的赠款提交来评估干预措施，以减少男女治疗和治疗特征的负面影响，并改善寻求治疗和药物滥用治疗的反应。实现这三个目标将记录我对独立的以患者为导向的研究人员的进步，并在评估和治疗滥用PTSD和其他合并症的男性和男性的评估和治疗方面认可专家。