Artherosclerosis/bone loss/drug use/HIV in older men

老年男性的动脉粥样硬化/骨质流失/吸毒/艾滋病毒

• 批准号: 6622527
• 负责人: Robert Stephen Klein
• 金额: $ 130.72万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622527
• 关键词: AIDS therapy; HIV infections; aging; antiAIDS agent; atherosclerosis; behavioral /social science research tag; cardiovascular disorder epidemiology; combination chemotherapy; comorbidity; diet; disease /disorder proneness /risk; human immunodeficiency virus; human middle age (35-64); human old age (65+); human subject; hypogonadism; insulin sensitivity /resistance; lipid disorder; longitudinal human study; male; nutrition of aging; obesity; pathologic bone resorption; patient oriented research; sex behavior; substance abuse epidemiology; substance abuse related disorder; urban area

As additional persons become infected with human immunodeficiency virus (HIV) an mortality due to this infection declines, more drug users and others with HIV infection will live to experience co-morbid conditions associated with aging. Some of these conditions appear likely to occur more commonly or to be more severe in persons with HIV infection, as a direct result of HIV infection or complications of its treatment. Presently there is little known about the possible effects of HIV infection and its treatments on diseases of aging in current or former drug users or other aging individuals. Prominent among such disorders commonly affecting older individuals are atherosclerotic disease and osteoporosis. To address these issues, we will conduct a five-year prospective study of aging, atherosclerosis, bone mass loss, and drug use in men 50 years or older with or at risk for HIV infection in the Bronx, New York City. A cohort of current or former drug users will be recruited from a longitudinal study, the Bronx HERO (HIV Epidemiological Research on Outcomes) Study, and from substance abuse treatment programs, other clinical care sites at our institutions, and the surrounding community. We will take advantage of an ongoing longitudinal study of older women drug users and other women with or at risk for HIV infection that is using similar methodology, in order to assess the role of gender on these conditions. The specific aims of the project are to: 1. Determine the effect of HIV infection and highly active antiretroviral therapy (HAART) on the rate and risk factors for atherosclerotic disease. Among risk factors to be considered will be dyslipidemia, insulin resistance, obesity, diet, and medication and illicit drug and alcohol use. 2. Determine the effect of HIV infection and HAART on age-related loss of bone mass. 3. Determine the effect of HIV infection and HAART on high-risk drug using and sexual behaviors of older men. 4. Take advantage of an ongoing study of a cohort of older women, which addresses similar issues using comparable methodology, in order to compare atherosclerosis, bone loss, and drug use and sexual behaviors in men and women.

随着其他人感染人类免疫缺陷病毒（HIV），由于这种感染而导致的死亡率下降，更多的吸毒者和其他感染感染的人将生活在体验与衰老有关的合并症。 这些疾病中的一些似乎可能发生更常见，或者在HIV感染的人中更为严重，这是HIV感染或治疗并发症的直接结果。 目前，关于艾滋病毒感染及其治疗对当前或前吸毒者或其他老龄化患者衰老的可能影响鲜为人知。 在这种疾病中，通常影响老年人的疾病中的突出是动脉粥样硬化疾病和骨质疏松症。 为了解决这些问题，我们将在纽约市布朗克斯市50岁以上的男性中对50岁或有艾滋病毒感染风险的男性进行五年的前瞻性研究。 将从一项纵向研究，布朗克斯英雄（艾滋病毒流行病学研究）研究以及药物滥用治疗计划，我们机构的其他临床护理现场以及周围社区中招募一组现任或前吸毒者。 我们将利用正在进行的纵向研究对使用类似方法的艾滋病毒感染或面临艾滋病毒感染风险或有风险的其他女性，以评估性别对这些疾病的作用。该项目的具体目的是：1。确定艾滋病毒感染和高度活跃的抗逆转录病毒疗法（HAART）对动脉粥样硬化疾病的率和危险因素的影响。 要考虑的危险因素包括血脂异常，胰岛素抵抗，肥胖，饮食，药物以及非法药物和酒精的使用。 2。确定HIV感染和HAART对年龄相关的骨骼量的影响。 3.使用老年男性的性行为确定HIV感染和HAART对高危药物的影响。 4。利用对一群老年妇女的持续研究，该研究使用可比的方法解决了类似的问题，以比较男性和女性的动脉粥样硬化，骨丢失以及药物使用和性行为。