Artherosclerosis/bone loss/drug use/HIV in older men

老年男性的动脉粥样硬化/骨质流失/吸毒/艾滋病毒

基本信息

批准号：
7050577
负责人：
Robert Stephen Klein
金额：
$ 110.98万
依托单位：
MONTEFIORE MEDICAL CENTER (BRONX, NY)
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至 2008-03-31
项目状态：
已结题

项目摘要

As additional persons become infected with human immunodeficiency virus (HIV) an mortality due to this infection declines, more drug users and others with HIV infection will live to experience co-morbid conditions associated with aging. Some of these conditions appear likely to occur more commonly or to be more severe in persons with HIV infection, as a direct result of HIV infection or complications of its treatment. Presently there is little known about the possible effects of HIV infection and its treatments on diseases of aging in current or former drug users or other aging individuals. Prominent among such disorders commonly affecting older individuals are atherosclerotic disease and osteoporosis. To address these issues, we will conduct a five-year prospective study of aging, atherosclerosis, bone mass loss, and drug use in men 50 years or older with or at risk for HIV infection in the Bronx, New York City. A cohort of current or former drug users will be recruited from a longitudinal study, the Bronx HERO (HIV Epidemiological Research on Outcomes) Study, and from substance abuse treatment programs, other clinical care sites at our institutions, and the surrounding community. We will take advantage of an ongoing longitudinal study of older women drug users and other women with or at risk for HIV infection that is using similar methodology, in order to assess the role of gender on these conditions. The specific aims of the project are to: 1. Determine the effect of HIV infection and highly active antiretroviral therapy (HAART) on the rate and risk factors for atherosclerotic disease. Among risk factors to be considered will be dyslipidemia, insulin resistance, obesity, diet, and medication and illicit drug and alcohol use. 2. Determine the effect of HIV infection and HAART on age-related loss of bone mass. 3. Determine the effect of HIV infection and HAART on high-risk drug using and sexual behaviors of older men. 4. Take advantage of an ongoing study of a cohort of older women, which addresses similar issues using comparable methodology, in order to compare atherosclerosis, bone loss, and drug use and sexual behaviors in men and women.

随着越来越多的人感染人类免疫缺陷病毒（HIV），这种感染导致的死亡率下降，更多的吸毒者和其他艾滋病毒感染者将经历与衰老相关的共病。其中一些病症似乎在艾滋病毒感染者中更常见或更严重，这是艾滋病毒感染或其治疗并发症的直接结果。目前，人们对艾滋病毒感染及其治疗对当前或以前的吸毒者或其他老年人的衰老疾病的可能影响知之甚少。通常影响老年人的此类疾病中最突出的是动脉粥样硬化性疾病和骨质疏松症。为了解决这些问题，我们将针对纽约市布朗克斯区 50 岁或以上感染 HIV 或有感染 HIV 风险的男性的衰老、动脉粥样硬化、骨质流失和吸毒情况开展一项为期五年的前瞻性研究。将从纵向研究、布朗克斯 HERO（艾滋病毒流行病学结果研究）研究、药物滥用治疗计划、我们机构的其他临床护理场所以及周边社区中招募一组当前或以前的吸毒者。我们将利用一项正在进行的针对老年女性吸毒者和其他感染艾滋病毒或有感染艾滋病毒风险的女性的纵向研究，该研究使用类似的方法，以评估性别在这些情况中的作用。该项目的具体目标是： 1. 确定 HIV 感染和高效抗逆转录病毒治疗 (HAART) 对动脉粥样硬化疾病发生率和危险因素的影响。需要考虑的危险因素包括血脂异常、胰岛素抵抗、肥胖、饮食、药物以及非法药物和酒精的使用。 2. 确定 HIV 感染和 HAART 对与年龄相关的骨量损失的影响。 3. 确定HIV感染和HAART对老年男性高危吸毒和性行为的影响。 4. 利用一项正在进行的老年女性队列研究，该研究使用可比方法解决类似问题，以比较男性和女性的动脉粥样硬化、骨质流失、吸毒和性行为。