GBS: Epidemiologic Characterization for Gene Discovery

GBS：基因发现的流行病学特征

• 批准号: 6576686
• 负责人: BETSY FOXMAN
• 金额: $ 51.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6576686
• 关键词: Streptococcus agalactiae; Streptococcus infection; bacterial genetics; chemical fingerprinting; clinical research; communicable disease transmission; drug resistance; epidemiology; gender difference; host organism interaction; human tissue; polymerase chain reaction; pregnancy infection; pulsed field gel electrophoresis; sex behavior; virulence

DESCRIPTION (provided by applicant): Group B Streptococcus (GBS) is a major cause of neonatal sepsis and meningitis. First emerging as a pathogen in newborn nurseries in the 1970s, it is now a pathogen of concern in nursing homes, intensive care units and outpatient settings. Little is known about GBS virulence factors. The overall goals of this application are 1) to use genetic fingerprinting techniques to better describe the molecular epidemiology of GBS of several epidemiologically defined collections; and 2) to identify new genes associated with GBS disease. By combining epidemiologic information with molecular genetics, we can maximize our ability to detect GBS virulence-related genes associated with invasive disease, extra-intestinal colonization, transmission and antibiotic resistance. This strategy also gives us insight as to the relative importance of the identified genes and their potential mechanism. A better understanding of the molecular epidemiology and the identification of new GBS virulence genes will facilitate the discovery of new therapies and prevention strategies for GBS disease.

描述（由申请人提供）：B 族链球菌 (GBS) 是新生儿败血症和脑膜炎的主要原因。它于 20 世纪 70 年代首次作为新生儿托儿所的病原体出现，现在已成为疗养院、重症监护室和门诊环境中令人关注的病原体。人们对 GBS 毒力因子知之甚少。该应用程序的总体目标是 1) 使用遗传指纹技术更好地描述几个流行病学定义的集合中 GBS 的分子流行病学； 2) 鉴定与 GBS 疾病相关的新基因。通过将流行病学信息与分子遗传学相结合，我们可以最大限度地提高检测与侵袭性疾病、肠外定植、传播和抗生素耐药性相关的 GBS 毒力相关基因的能力。这一策略还让我们深入了解已识别基因的相对重要性及其潜在机制。更好地了解分子流行病学和识别新的 GBS 毒力基因将有助于发现 GBS 疾病的新疗法和预防策略。