SIGNALING PATHWAYS & TRANSCRIPTIONAL REGULATION

信号通路

• 批准号: 6608833
• 负责人: IAN M WILLIS
• 金额: $ 26.72万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608833
• 关键词: DNA directed RNA polymerase; Saccharomyces cerevisiae; biological signal transduction; cell growth regulation; cyclins; genetic transcription; ribonuclease III; secretion

DESCRIPTION(adapted from applicant's abstract): Transcription of the large ribosomal RNAs and ribosomal protein mRNAs account for more than 70 percent of nuclear transcription and must be under tight control to prevent their energetically costly synthesis at inappropriate times. The transcription of these ribosomal RNAs is coordinately regulated to ensure the synthesis of stoichiometric amounts of ribosomal components and optimal levels of protein synthetic substrates. And prevent their energetically costly synthesis at inappropriate times. The long term goal of the proposed application is to elucidate the relationship between cell proliferation and transcription of the protein synthetic machinery.

描述（改编自申请人的摘要）：大的转录 核糖体RNA和核糖体蛋白mRNA占70％以上 核转录，必须处于严格的控制之下，以防止其 在不适当的时期，能量昂贵的综合。转录 这些核糖体RNA经过协调调节，以确保合成 化学计量量的核糖体成分和最佳蛋白质水平 合成底物。并防止其能量昂贵的合成 不适当的时期。拟议申请的长期目标是 阐明细胞增殖与转录之间的关系 蛋白质合成机械。