SIGNALING PATHWAYS & TRANSCRIPTIONAL REGULATION

信号通路

• 批准号: 6520161
• 负责人: IAN M WILLIS
• 金额: $ 26.72万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6520161
• 关键词: DNA directed RNA polymerase; Saccharomyces cerevisiae; biological signal transduction; cell growth regulation; cyclins; genetic transcription; ribonuclease III; secretion

DESCRIPTION(adapted from applicant's abstract): Transcription of the large ribosomal RNAs and ribosomal protein mRNAs account for more than 70 percent of nuclear transcription and must be under tight control to prevent their energetically costly synthesis at inappropriate times. The transcription of these ribosomal RNAs is coordinately regulated to ensure the synthesis of stoichiometric amounts of ribosomal components and optimal levels of protein synthetic substrates. And prevent their energetically costly synthesis at inappropriate times. The long term goal of the proposed application is to elucidate the relationship between cell proliferation and transcription of the protein synthetic machinery.

描述（改编自申请人的摘要）：大篇幅的转录 核糖体RNA和核糖体蛋白mRNA占70%以上 核转录必须受到严格控制以防止其发生 在不适当的时间进行能量消耗巨大的合成。的转录 这些核糖体 RNA 受到协调调节，以确保合成 核糖体成分的化学计量和蛋白质的最佳水平 合成基材。并防止它们在 不适当的时间。拟议应用程序的长期目标是 阐明细胞增殖与转录的关系 蛋白质合成机械。