Integrating Behavioral and Molecular Genetics

整合行为和分子遗传学

基本信息

批准号：
6604304
负责人：
DANIELLE M DICK
金额：
$ 1.23万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-08-31 至 2003-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6604304
关键词：
alcoholism /alcohol abuse behavioral /social science research tag behavioral genetics bipolar depression clinical research family genetics gene environment interaction genetic models genetic susceptibility genotype human data interdisciplinary collaboration model design /development molecular genetics phenotype postdoctoral investigator

项目摘要

Despite substantial evidence for the heritability of behavioral and psychiatric disorders, complex modes of inheritance have complicated efforts to identify dispositional genes. New strategies to enhance our ability to detect genes involved in complex disorders are needed. Utilizing behavior genetic techniques to inform molecular analyses provides a potentially powerful strategy. Behavior genetic analyses can measure the extent to which different traits are influenced by the same genes; thus, novel phenotypes can be developed for genetic analyses that more accurately reflect the genetic susceptibilities we are trying to detect. Additionally, behavior genetic analyses can elucidate how specific environmental influences interact with dispositional genes. This information can be incorporated in molecular analyses to enhance our ability to detect susceptibility genes. Finally, once vulnerability regions are identified, clinical psychologists will play an important role in translating this knowledge into improved clinical assessment and intervention. Research bridging the gap between clinical psychology and genetics holds the potential to vastly improve our understanding of the etiology and treatment of behavioral and psychiatric disorders. My postdoctoral training proposal is illustrative of this interdisciplinary approach, with specific application to the area of alcohol use and abuse.

尽管有大量证据表明行为和精神疾病具有遗传性，但复杂的遗传模式使识别倾向基因的工作变得复杂。需要新的策略来增强我们检测与复杂疾病相关的基因的能力。利用行为遗传学技术为分子分析提供信息提供了一种潜在的强大策略。行为遗传分析可以测量不同性状受相同基因影响的程度；因此，可以开发新的表型用于遗传分析，更准确地反映我们试图检测的遗传易感性。此外，行为遗传分析可以阐明特定的环境影响如何与性格基因相互作用。这些信息可以纳入分子分析中，以增强我们检测易感基因的能力。最后，一旦确定了脆弱区域，临床心理学家将在将这些知识转化为改进的临床评估和干预方面发挥重要作用。弥合临床心理学和遗传学之间差距的研究有可能极大地提高我们对行为和精神疾病的病因和治疗的理解。我的博士后培训计划说明了这种跨学科方法，特别适用于酒精使用和滥用领域。