Twin, molecular, and developmental approaches to understanding alcohol misuse

理解酒精滥用的双生、分子和发育方法

基本信息

批准号：
8606719
负责人：
DANIELLE M DICK
金额：
$ 12.11万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8606719
关键词：
Address Adolescence Adult Affect African American Age Aggressive behavior Alabama Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcohols Architecture Area Attention deficit hyperactivity disorder Behavior Behavioral Characteristics Child Child Development Childhood Cognitive Communities Complex Conduct Disorder Data Data Analyses Data Collection Dependence Development Development Plans Diagnosis Disease Enrollment Environment Environmental Risk Factor Epidemiology Funding General Population Genes Genetic Goals Home environment Impulsivity Independent Scientist Award Individual Interview Longitudinal Studies Measures Methodology Minority Molecular Molecular Genetics Mothers National Institute on Alcohol Abuse and Alcoholism Nature Neighborhoods Oppositional Defiant Disorder Parent-Child Relations Parenting behavior Parents Pathway interactions Pattern Peer Group Peer Review Phenotype Population Preventive Intervention Problem behavior Request for Applications Research Research Design Research Project Grants Research Support Risk Risk Factors Role Sales Sampling Social support Structure Substance Use Disorder Susceptibility Gene Symptoms Temperament Testing Time Twin Multiple Birth Twin Studies Virginia Youth addiction adolescent substance use alcohol misuse alcohol related problem alcohol research alcohol use disorder anti social base career career development clinical Diagnosis cohesion cohort conduct problem design deviant early childhood early onset substance use externalizing behavior genetic analysis genetic association genetics of alcoholism genome wide association study high risk high school indexing parental monitoring peer population based pregnant programs pubertal timing public health relevance racial difference research and development risk variant self esteem stem teacher trait underage drinking young adult

项目摘要

DESCRIPTION (provided by applicant): Integrating Twin, Molecular, and Developmental Approaches to Understanding Alcohol Misuse: This application requests funding for a five year K02 award, with the overarching goal of developing an interdisciplinary program of research aimed at advancing our understanding of how genetic influences impact the development of alcohol use disorders. This will be accomplished by integrating findings across twin studies, gene identification projects, and longitudinal, community-based samples. The research plan has three broad aims: (1) To use twin studies to characterize the nature of genetic and environmental influences on alcohol use and related disorders, with focus on (a) studying the changing influence of genetic effects as a function of the environment and across development, and (b) understanding how genetic influences impact the phenotypic spectrum of risk associated with alcohol use disorders. The second aim (2) is to identify genes involved in alcohol use and related phenotypes. The third aim (3) is to characterize the risk associated with identified genes using community-based samples of individuals studied longitudinally, to test how the effect associated with specific genes may change across development and in conjunction with specific environmental factors. These aims will be accomplished by integrating data across several of my funded projects: two population-based twin samples, FinnTwin12 and the Virginia Adult Twin Study of Psychiatric and Substance Use disorders; two gene identification projects: the Collaborative Study on the Genetics of Alcoholism and the Irish Affected Sib Pair Study of Alcohol Dependence; and three longitudinal, community-based samples: the Child Development Project, a study of ~500 children followed annually from age 5-25; the Mobile Youth Study, an on-going study of African-American children ages 10-18 from high-risk, impoverished neighborhoods; and the Avon Longitudinal Study of Parents and Children, an epidemiological cohort of ~10,000 children enrolled from a geographically-limited region in the UK, and assessed repeatedly (minimally yearly) prenatally through young adulthood. Accordingly, this project integrates findings across a number of research approaches, using results from twin studies about the nature of genetic influences (Aim 1) to develop hypotheses to test about the risk associated with specific genes (identified in Aim 2) in longitudinal, community samples (Aim 3). Together, these studies will synergize to advance our understanding of how genetic and environmental factors come together to influence to the development of alcohol problems. To inform my ability to conduct the proposed analyses, focused career development is proposed in two new content areas: (i) early childhood risk factors for alcohol problems, and (ii) racial differences in risk factors for alcohol problems, and two methodological areas: (i) GWAS methodology, and (ii) longitudinal data analyses. These stem directly from my funded projects and represent expansions to my current areas of expertise in alcohol research.

描述（由申请人提供）：整合孪生、分子和发育方法来理解酒精滥用：该申请要求为五年 K02 奖提供资金，其总体目标是开发一个跨学科研究计划，旨在增进我们对遗传如何影响酒精滥用的理解。影响酒精使用障碍的发展。这将通过整合双胞胎研究、基因鉴定项目和纵向、基于社区的样本的发现来实现。该研究计划有三大目标：(1) 利用双胞胎研究来表征遗传和环境对酒精使用和相关疾病影响的性质，重点是 (a) 研究遗传效应随环境变化的影响以及（b）了解遗传影响如何影响与酒精使用障碍相关的风险表型谱。第二个目标 (2) 是鉴定与饮酒和相关表型有关的基因。第三个目标 (3) 是使用基于社区的纵向研究个体样本来表征与已识别基因相关的风险，以测试与特定基因相关的效应如何在发育过程中以及与特定环境因素相结合的情况下发生变化。这些目标将通过整合我资助的几个项目的数据来实现：两个基于人群的双胞胎样本，FinnTwin12 和弗吉尼亚成人双胞胎精神和药物使用障碍研究；两个基因鉴定项目：酗酒遗传学合作研究和爱尔兰受影响同胞对酒精依赖研究；以及三个基于社区的纵向样本：儿童发展项目，一项每年对 500 名 5-25 岁儿童进行跟踪调查的研究；流动青年研究，一项针对来自高风险、贫困社区的 10 至 18 岁非裔美国儿童的持续研究；雅芳父母和儿童纵向研究，这是一个流行病学队列，招募了来自英国地理有限区域的约 10,000 名儿童，并从产前到成年早期进行反复评估（至少每年一次）。因此，该项目整合了多种研究方法的发现，利用关于遗传影响本质的双胞胎研究结果（目标 1）来提出假设，以测试纵向社区中与特定基因（目标 2 中确定的）相关的风险。样品（目标 3）。这些研究将共同促进我们对遗传和环境因素如何共同影响酒精问题的发展的理解。为了让我有能力进行拟议的分析，建议在两个新的内容领域进行重点职业发展：（i）幼儿酒精问题的风险因素，（ii）酒精问题风险因素的种族差异，以及两个方法领域： (i) GWAS 方法，以及 (ii) 纵向数据分析。这些直接源于我资助的项目，代表了我目前酒精研究专业领域的扩展。