Long term effects of trauma on amygdala and HPA activity

创伤对杏仁核和 HPA 活性的长期影响

• 批准号: 6742041
• 负责人: Barbara Lynn Ganzel
• 金额: $ 3.97万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6742041
• 关键词: adolescence (12-20); adult human (21+); age difference; amygdala; behavioral /social science research tag; children; clinical research; cortisol; developmental neurobiology; disasters; functional magnetic resonance imaging; human subject; hypothalamic pituitary axis; interview; peripheral nervous system; postdoctoral investigator; psychological shock; stress

DESCRIPTION (provided by applicant): Research suggests that psychological trauma may produce sensitization of the amygdala and related regions simultaneously with desensitization of the hypothalamus-pituitary axis (HPA) system of the PNS. There are no studies to date that simultaneously examine the central and peripheral effects of trauma, and none that compare the long-term effects of trauma on the amygdala in children relative to adults. The proposed study compares a non-clinical sample of children (n=24) and adults (n=24) who were within a mile of the World Trade Center (WTC) on 9/11/01 to matched control groups who lived at least 300 miles away from the New York City or Washington, D.C. areas between 9/11/01 and 9/11/02. FMRI will be used to measure amygdala activation; subjects will view blocks of fearful and neutral faces, a paradigm that has been used previously to study amygdala function in children and adults. The peripheral stress response will be measured through salivary cortisol production, assessed as diurnal change and as acute change due to the fMRI process itself. It is hypothesized that children and adults who have been exposed to trauma will show hyperactivity in the CRF system (amygdala activity) and hypoactivity in the HPA system (cortisol response).

描述（由申请人提供）：研究表明，心理创伤可能会导致杏仁核和相关区域敏感，同时导致三七总皂苷的下丘脑-垂体轴（HPA）系统脱敏。迄今为止，还没有研究同时检查创伤对中枢和外周的影响，也没有研究比较创伤对儿童与成人杏仁核的长期影响。拟议的研究将 2001 年 9 月 11 日居住在世界贸易中心 (WTC) 一英里范围内的儿童 (n=24) 和成人 (n=24) 的非临床样本与居住在至少2001 年 9 月 11 日至 2002 年 9 月 11 日期间距纽约市或华盛顿特区 300 英里的地区。 FMRI 将用于测量杏仁核激活情况；受试者将看到恐惧和中性面孔的块，这是以前用于研究儿童和成人杏仁核功能的范例。外周应激反应将通过唾液皮质醇的产生来测量，评估为昼夜变化和功能磁共振成像过程本身引起的急性变化。据推测，遭受过创伤的儿童和成人会表现出 CRF 系统（杏仁核活动）过度活跃和 HPA 系统（皮质醇反应）活动减退。