Nanoengineered hybrid coatings that control inflammation to artificial bone

控制人造骨炎症的纳米工程混合涂层

• 批准号: DP240103271
• 负责人: Prof Peter Kingshott
• 金额: $ 39.39万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103271
• 关键词: Nanoengineered; hybrid; coatings; control; inflammation

This project aims to develop novel biocompatible surfaces using nanotechnology approaches to understand how cells attach to and grow on artificial bone materials. This research is significant because it combines novel nanofabrication and surface modification strategies for unprecedented control and manipulation of inflammatory cell behaviour relevant to orthopaedic implants. The project will overcome current limitations of uncontrollable inflammatory reactions to surfaces. The multifunctional surfaces are expected to give the biomaterials field new tools to control and maintain bone cell functionality, in vitro. Potential long-term benefits include applications as coatings in tissue engineering, regenerative medicine, and medical implants.

该项目旨在使用纳米技术方法开发新型的生物相容性表面，以了解细胞如何在人造骨料上附着并生长。这项研究之所以重要，是因为它结合了新型的纳米化制作和表面修饰策略，用于对与骨科植入物相关的炎症细胞行为进行前所未有的控制和操纵。该项目将克服目前对表面不可控制的炎症反应的局限性。预计多功能表面将为生物材料场提供新的工具，以控制和维持体外的骨细胞功能。潜在的长期收益包括在组织工程，再生医学和医疗植入物中的涂料应用。