Multiplexed surface signals to inhibit mixed bacterial biofilm formation

多重表面信号抑制混合细菌生物膜形成

• 批准号: DP210102027
• 负责人: Prof Peter Kingshott
• 金额: $ 34.83万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102027
• 关键词: Multiplexed; surface; signals; inhibit; mixed

This project aims to investigate a novel class of multifunctional surfaces that can be used to coat biomaterials with antimicrobial properties. This combines advanced polymer synthesis with a new colloidal particle self-assembly technique to modify surfaces. Expected project outcomes are generation of new knowledge of the molecular mechanisms of biofilm formation in complex microbial communities, which may facilitate future research exploring the development of biomaterials that resist attachment of infectious microbes, which is desperately needed in many biomedical application areas. This can assist entrepreneurs and researchers in the medical technologies sector, allowing them to explore how to reduce infection rates on medical devices.

该项目旨在研究一类新型的多功能表面，这些表面可用于将生物材料具有抗菌特性覆盖。这将高级聚合物合成与一种新的胶体颗粒自组装技术结合在一起，以修饰表面。预期的项目结果是对复杂微生物群落中生物膜形成的分子机制的新知识的产生，这可能促进了未来的研究，探讨了抗拒感染微生物的附着的生物材料的发展，这些生物材料在许多生物医学应用领域迫切需要。这可以帮助医疗技术领域的企业家和研究人员，从而探索如何降低医疗设备上的感染率。