AGE & SYMPATHETIC METABOLIC CARDIOVASCULAR REGULATION

年龄

• 批准号: 6509358
• 负责人: PAMELA P JONES
• 金额: $ 12.24万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509358
• 关键词: adult human (21+); age difference; aging; baroreflex; bioenergetics; blood glucose; cardiac output; cardiovascular function; clinical research; exercise; geriatrics; heart rate; human old age (65+); human subject; hypotension; insulin; neuroregulation; nutrition of aging; nutrition related tag; oxygen consumption; sympathetic nervous system

The applicant, Pamela P. Jones, Ph.D., is a physiologist currently supported by an Individual National Research Service Award from NIA. Dr. Jones has demonstrated a consistent focus and record of research productivity in the area of autonomic nervous system (ANS) regulation of energy metabolism and cardiovascular function in humans. Her career goal is to develop an independent, extramurally-funded research program in this area as it pertains to gerontology and geriatric medicine. The KO1 Mentored Research Scientist Development Award would provide the opportunity to extend her current research skills to achieve this goal. Career Development/Training Plan. The training plan consists of 2 primary elements: 1) the acquisition of an impressive number of new research skills; and 2) structured activities including formal course- work in research ethics, biostatistics, and gerontology/geriatric medicine; participation in journal clubs and seminar series; regular mentoring interactions; and attendance/presentation at scientific meetings. A team of established senior investigators with expertise in all aspects of the proposed training plan has been formed to mentor Dr. Jones. Research Plan. The central theme of the research project is to determine the role of the ANS in the attenuated increase in energy expenditure (reduced thermic effect of food-TEF) and the fall in arterial blood pressure (postprandial hypotension) associated with feeding in older healthy sedentary humans. A secondary theme will be to determine if older adults who exercise regularly demonstrate a greater TEF and an absence of postprandial hypotension compared to sedentary older adults. Five specific aims have been developed to address these issues. The general hypothesis is that the lower TEF and postprandial hypotension observed in older sedentary adults will be related to an attenuated increase in sympathetic nervous system (SNS) activity. In contrast, physically active older adults will, in comparison, demonstrate a greater TEF, no postprandial hypotension, and an augmented SNS response. The expected results should provide new and clinically useful information concerning the influences of sedentary aging and habitual physical activity on an important component of body weight regulation (TEF) as well as cardiovascular disease risk (postprandial hypotension). Environment. The environment for Dr. Jones training is excellent. The sponsor, Douglas R. Seals, Ph.D., is an established investigator and mentor in aging research, and has a well-funded laboratory. He and the host department will provide Dr. Jones all of the necessary resources to successfully complete her training.

申请人Pamela P. Jones博士是生理学家 由NIA的个人国家研究服务奖的支持。 琼斯博士表现出一致的重点和研究记录 自主神经系统（ANS）法规领域的生产力 人类的能量代谢和心血管功能。 她的职业生涯 目标是制定一个独立的，外部资助的研究计划 在该领域，它与老年医学和老年医学有关。 这 KO1指导研究科学家发展奖将为 扩展她当前的研究技能以实现这一目标的机会。 职业发展/培训计划。 培训计划包括2 主要要素：1）获得了令人印象深刻的新数量 研究技能； 2）结构化活动，包括正式课程 - 研究伦理学，生物统计学和老年医学/老年研究 药品;参加期刊俱乐部和研讨会系列；常规的 指导互动；以及科学的出席/演讲 会议。 一支拥有专业知识的成熟高级调查员团队 在拟议的培训计划的各个方面，已经制定了指导者 琼斯博士。 研究计划。研究项目的中心主题是确定 ANS在能量支出增加的衰减中的作用 （食物-TEF的热效应降低）和动脉血下的下降 与年龄较大的喂养相关的压力（餐后低血压） 健康久坐的人。 次要主题是确定是否 定期运动的老年人表现出更大的TEF和 与久坐的老年人相比，餐后低血压没有。 已经开发了五个具体目标来解决这些问题。这 一般假设是较低的TEF和餐后低血压 在老年久坐的成年人中观察到的 交感神经系统（SNS）活动的增加。 相比之下， 相比之下，身体活跃的老年人将证明 更大的TEF，没有餐后低血压和增强的SNS反应。 预期的结果应提供新的和临床上有用的结果 有关久坐衰老和习惯的影响的信息 体重调节的重要组成部分的体育活动 （TEF）以及心血管疾病风险（餐后低血压）。 环境。 琼斯博士培训的环境非常好。 这 赞助商道格拉斯·R·海·海斯（Douglas R. Seals）博士是一位既定的研究员， 老化研究的导师，并拥有资金充足的实验室。 他和 东道国将向琼斯博士提供所有必要的资源 成功完成她的培训。