SYMPATHETIC NERVE ACTIVITY AND ADIPOSITY IN HUMAN AGING

人类衰老过程中的交感神经活动和肥胖

• 批准号: 6026899
• 负责人: PAMELA P JONES
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-10-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6026899
• 关键词: adipose tissue; aging; body composition; neuromuscular function; sympathetic nervous system

The sympathetic nervous system plays an important role in the regulation of metabolic and cardiovascular function. There is a well documented rise in sympathetic nerve activity to skeletal muscle (MSNA) at rest with aging in humans. The general experimental goal of the proposed studies will be to investigate one possible mechanism responsible for this age- related rise in tonic levels of MSNA. The specific aims are to determine: 1) if increases in total body fat (hyrodensitometry), total abdominal and abdominal visceral fat (computed tomography) with age are related to the increase in MSNA (microneurography); 2) if reductions in these same measures of body fat in older humans by caloric restriction are associated with decreases in MSNA; 3) if increases in these levels of body fat in young humans produced by over-feeding are associated with increases in MSNA; and 4) if changes in resting metabolic rate (RMR, open-circuit spirometry) are positively related to changes in MSNA. It is hypothesized that the measures of body fat will be directly related to MSNA and will contribute significantly to the age differences. Furthermore, changes in MSNA and RMR will be directly related to changes in total body, total abdominal, and abdominal visceral fat after the dietary interventions. The results of these studies will provide insight into one mechanism responsible for increased MSNA with age. This is important in light of the growing recognition of the role of the sympathetic nervous system in the physiology and pathophysiology of human aging.

交感神经系统在调节中起着重要作用 代谢和心血管功能。有一个有据可查的崛起 与骨骼肌（MSNA）的交感神经活动中 人类衰老。拟议研究的一般实验目标 将调查导致该年龄的一种可能机制 - MSNA补品水平的相关上升。具体目的是确定： 1）如果总体脂肪（氢气测定法）增加，总腹部和 年龄的腹部内脏脂肪（计算机断层扫描）与 MSNA的增加（微功能学）； 2）如果这些减少 通过热量限制，年龄较大的人体内脂肪的度量是 与MSNA减少有关； 3）如果这些水平增加 通过过度喂养产生的年轻人的体内脂肪与 MSNA的增加； 4）如果静息代谢率的变化（RMR， 开路肺活量测定法）与MSNA的变化呈正相关。它 假设体内脂肪的度量将直接相关 到MSNA，将对年龄差异产生重大贡献。 此外，MSNA和RMR的变化将与变化直接相关 在总体中，腹部总体和腹部内脏脂肪之后 饮食干预措施。这些研究的结果将提供洞察力 成为一种导致MSNA随着年龄增长的机制。这是 鉴于人们对对角色的作用的认识日益重要 人类生理和病理生理学中的交感神经系统 老化。